American Journal of Neuroradiology, Vol 16, Issue 2 265-268, Copyright © 1995 by American Society of Neuroradiology
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Contrast enhancement in spinal nerve roots: an experimental study
C Nguyen, VM Haughton, KC Ho, HS An, JB Myklebust, T Hasegawa, R Xu and JM Harb
Department of Radiology, Medical College of Wisconsin, Milwaukee, USA.
PURPOSE: To examine histopathologically the endothelium of contrast- enhancing spinal nerve roots. METHODS: In five adult baboons, chronic compression of the left S-1 spinal nerve root sufficient to produce a change in the evoked potential was produced by means of a suture tied around the nerve. The animals were studied with MR at 8 and 16 days after nerve compression and then killed for histopathologic and electron microscopic studies. Histopathologic changes in the nerve roots demonstrating contrast enhancement were described. RESULTS: In all compressed spinal nerves, contrast enhancement was observed. Histopathologically, wallerian degeneration of the root and inflammation and disruption of the endothelium of capillaries in the spinal nerve were evident. CONCLUSIONS: Degenerative changes in the nerve root and the capillary endothelium of a lumbar spinal nerve are associated with contrast enhancement.
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