American Journal of Neuroradiology, Vol 16, Issue 2 361-371, Copyright © 1995 by American Society of Neuroradiology
ARTICLES |
In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with structural alteration in gliomas of the cerebral hemispheres [published erratum appears in AJNR Am J Neuroradiol 1995 Jun-Jul;16(6):1384]
JA Brunberg, TL Chenevert, PE McKeever, DA Ross, LR Junck, KM Muraszko, R Dauser, JG Pipe and AT Betley
Department of Radiology, University of Michigan Hospitals, Ann Arbor, USA.
PURPOSE: To determine whether a relationship exists between water diffusion coefficients or diffusion anisotropy and MR-defined regions of normal or abnormal brain parenchyma in patients with cerebral gliomas. METHODS: In 40 patients with cerebral gliomas, diffusion was characterized in a single column of interest using a motion-insensitive spin-echo sequence that was applied sequentially at two gradient strength settings in three orthogonal directions. Apparent diffusion coefficients (ADCs) were derived for the three orthogonal axes at 128 points along the column. An average ADC and an index of diffusion anisotropy (IDA = diffusion coefficientmax-min/diffusionmean) was than calculated for any of nine MR-determined regions of interest within the tumor or adjacent parenchyma. RESULTS: In cerebral edema, mean ADC (all ADCs as 10(-7) cm2/s) was 138 +/- 24 (versus 83 +/- 6 for normal white matter) with mean IDA of 0.26 +/- 0.14 (versus 0.45 +/- 0.17 for normal white matter). Solid enhancing central tumor mean ADC was 131 +/- 25 with mean IDA of 0.15 +/- 0.10. Solid enhancing tumor margin mean ADC was 131 +/- 25, with IDA of 0.25 +/- 0.20. Cyst or necrosis mean ADC was 235 +/- 35 with IDA of 0.07 +/- 0.04. CONCLUSION: In cerebral gliomas ADC and IDA determinations provide information not available from routine MR imaging. ADC and IDA determinations allow distinction between normal white matter, areas of necrosis or cyst formation, regions of edema, and solid enhancing tumor. ADCs can be quickly and reliably characterized within a motion-insensitive column of interest with standard MR hardware.
This article has been cited by other articles:
 |
|
 |
|
  M. Horger, M. Fenchel, T. Nagele, R. Moehle, C. D. Claussen, R. Beschorner, and U. Ernemann Water Diffusivity: Comparison of Primary CNS Lymphoma and Astrocytic Tumor Infiltrating the Corpus Callosum Am. J. Roentgenol., November 1, 2009; 193(5): 1384 - 1387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I-C CHIANG, T-J HSIEH, M-L CHIU, G-C LIU, Y-T KUO, and W-C LIN Distinction between pyogenic brain abscess and necrotic brain tumour using 3-tesla MR spectroscopy, diffusion and perfusion imaging Br. J. Radiol., October 1, 2009; 82(982): 813 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Pichiecchio, E Tavazzi, G Maccabelli, C. Precupanu, A Romani, L Roccatagliata, G Luccichenti, R Bergamaschi, and S Bastianello What insights have new imaging techniques given into aggressive forms of MS - different forms of MS or different from MS? Multiple Sclerosis, March 1, 2009; 15(3): 285 - 293. [Abstract] [PDF]
|
|
|
|
|
|
T NIWA, M UENO, S OHKAWA, T YOSHIDA, T DOIUCHI, K ITO, and T INOUE Advanced pancreatic cancer: the use of the apparent diffusion coefficient to predict response to chemotherapy Br. J. Radiol., January 1, 2009; 82(973): 28 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mukherjee, J.I. Berman, S.W. Chung, C.P. Hess, and R.G. Henry Diffusion Tensor MR Imaging and Fiber Tractography: Theoretic Underpinnings AJNR Am. J. Neuroradiol., April 1, 2008; 29(4): 632 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Toh, M. Castillo, A.M.-C. Wong, K.-C. Wei, H.-F. Wong, S.-H. Ng, and Y.-L. Wan Primary Cerebral Lymphoma and Glioblastoma Multiforme: Differences in Diffusion Characteristics Evaluated with Diffusion Tensor Imaging AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 471 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.S. Kim and S.Y. Kim A Prospective Study on the Added Value of Pulsed Arterial Spin-Labeling and Apparent Diffusion Coefficients in the Grading of Gliomas AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1693 - 1699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Goebell, S. Paustenbach, O. Vaeterlein, X.-Q. Ding, O. Heese, J. Fiehler, T. Kucinski, C. Hagel, M. Westphal, and H. Zeumer Low-Grade and Anaplastic Gliomas: Differences in Architecture Evaluated with Diffusion-Tensor MR Imaging Radiology, April 1, 2006; 239(1): 217 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Jacobs, E. H. Herskovits, and H. S. Kim Uterine Fibroids: Diffusion-weighted MR Imaging for Monitoring Therapy with Focused Ultrasound Surgery--Preliminary Study Radiology, July 1, 2005; 236(1): 196 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Kuhl, J. Gieseke, M. von Falkenhausen, J. Textor, S. Gernert, C. Sonntag, and H. H. Schild Sensitivity Encoding for Diffusion-weighted MR Imaging at 3.0 T: Intraindividual Comparative Study Radiology, February 1, 2005; 234(2): 517 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Roth, T. Tichler, G. Kostenich, J. Ruiz-Cabello, S. E. Maier, J. S. Cohen, A. Orenstein, and Y. Mardor High-b-Value Diffusion-weighted MR Imaging for Pretreatment Prediction and Early Monitoring of Tumor Response to Therapy in Mice Radiology, September 1, 2004; 232(3): 685 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Provenzale, P. McGraw, P. Mhatre, A. C. Guo, and D. Delong Peritumoral Brain Regions in Gliomas and Meningiomas: Investigation with Isotropic Diffusion-weighted MR Imaging and Diffusion-Tensor MR Imaging Radiology, August 1, 2004; 232(2): 451 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lu, D. Ahn, G. Johnson, M. Law, D. Zagzag, and R. I. Grossman Diffusion-Tensor MR Imaging of Intracranial Neoplasia and Associated Peritumoral Edema: Introduction of the Tumor Infiltration Index Radiology, July 1, 2004; 232(1): 221 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Hein, C. J. Eskey, J. F. Dunn, and E. B. Hug Diffusion-Weighted Imaging in the Follow-up of Treated High-Grade Gliomas: Tumor Recurrence versus Radiation Injury AJNR Am. J. Neuroradiol., February 1, 2004; 25(2): 201 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bilgili and B. Unal Effect of Region of Interest on Interobserver Variance in Apparent Diffusion Coefficient Measures AJNR Am. J. Neuroradiol., January 1, 2004; 25(1): 108 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Nelson Multivoxel Magnetic Resonance Spectroscopy of Brain Tumors Mol. Cancer Ther., May 1, 2003; 2(5): 497 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Bulakbasi, M. Kocaoglu, F. Ors, C. Tayfun, and T. Ucoz Combination of Single-Voxel Proton MR Spectroscopy and Apparent Diffusion Coefficient Calculation in the Evaluation of Common Brain Tumors AJNR Am. J. Neuroradiol., February 1, 2003; 24(2): 225 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Guo, T. J. Cummings, R. C. Dash, and J. M. Provenzale Lymphomas and High-Grade Astrocytomas: Comparison of Water Diffusibility and Histologic Characteristics Radiology, July 1, 2002; 224(1): 177 - 183. [Abstract] [Full Text]
|
|
|
|
|
|
A. Rovira, I. Pericot, J. Alonso, J. Rio, E. Grive, and X. Montalban Serial Diffusion-Weighted MR Imaging and Proton MR Spectroscopy of Acute Large Demyelinating Brain Lesions: Case Report AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 989 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sinha, M. E. Bastin, I. R. Whittle, and J. M. Wardlaw Diffusion Tensor MR Imaging of High-Grade Cerebral Gliomas AJNR Am. J. Neuroradiol., April 1, 2002; 23(4): 520 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chu, D.-W. Kang, D.-E. Kim, S.-H. Park, and J.-K. Roh Diffusion-Weighted and Gradient Echo Magnetic Resonance Findings of Hemichorea-Hemiballismus Associated With Diabetic Hyperglycemia: A Hyperviscosity Syndrome? Arch Neurol, March 1, 2002; 59(3): 448 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. J. Zhou, N. E. Leeds, G. C. McKinnon, and A. J. Kumar Characterization of Benign and Metastatic Vertebral Compression Fractures with Quantitative Diffusion MR Imaging AJNR Am. J. Neuroradiol., January 1, 2002; 23(1): 165 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Gauvain, R. C. McKinstry, P. Mukherjee, A. Perry, J. J. Neil, B. A. Kaufman, and R. J. Hayashi Evaluating Pediatric Brain Tumor Cellularity with Diffusion-Tensor Imaging Am. J. Roentgenol., August 1, 2001; 177(2): 449 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kono, Y. Inoue, K. Nakayama, M. Shakudo, M. Morino, K. Ohata, K. Wakasa, and R. Yamada The Role of Diffusion-weighted Imaging in Patients with Brain Tumors AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1081 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Maier, P. Bogner, G. Bajzik, H. Mamata, Y. Mamata, I. Repa, F. A. Jolesz, and R. V. Mulkern Normal Brain and Brain Tumor: Multicomponent Apparent Diffusion Coefficient Line Scan Imaging Radiology, June 1, 2001; 219(3): 842 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Stadnik, C. Chaskis, A. Michotte, W. M. Shabana, K. van Rompaey, R. Luypaert, L. Budinsky, V. Jellus, and M. Osteaux Diffusion-weighted MR Imaging of Intracerebral Masses: Comparison with Conventional MR Imaging and Histologic Findings AJNR Am. J. Neuroradiol., May 1, 2001; 22(5): 969 - 976. [Abstract] [Full Text]
|
|
|
|
|
|
K. Kantarci, C. R. Jack Jr, Y. C. Xu, N. G. Campeau, P. C. O’Brien, G. E. Smith, R. J. Ivnik, B. F. Boeve, E. Kokmen, E. G. Tangalos, et al. Mild Cognitive Impairment and Alzheimer Disease: Regional Diffusivity of Water Radiology, April 1, 2001; 219(1): 101 - 107. [Abstract] [Full Text]
|
|
|
|
|
|
S. Higano, J. Zhong, D. A. Shrier, D. K. Shibata, Y. Takase, H. Wang, and Y. Numaguchi Diffusion Anisotropy of the Internal Capsule and the Corona Radiata in Association with Stroke and Tumors as Measured by Diffusion-weighted MR Imaging AJNR Am. J. Neuroradiol., March 1, 2001; 22(3): 456 - 463. [Abstract] [Full Text]
|
|
|
|
|
|
P. W. Schaefer, P. E. Grant, and R. G. Gonzalez Diffusion-weighted MR Imaging of the Brain Radiology, November 1, 2000; 217(2): 331 - 345. [Abstract] [Full Text]
|
|
|
|
|
|
A. G. Sorensen, O. Wu, W. A. Copen, T. L. Davis, R. G. Gonzalez, W. J. Koroshetz, T. G. Reese, B. R. Rosen, V. J. Wedeen, and R. M. Weisskoff Human Acute Cerebral Ischemia: Detection of Changes in Water Diffusion Anisotropy by Using MR Imaging Radiology, September 1, 1999; 212(3): 785 - 792. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. W. Schaefer, F. S. Buonanno, R. G. Gonzalez, and L. H. Schwamm Diffusion-Weighted Imaging Discriminates Between Cytotoxic and Vasogenic Edema in a Patient With Eclampsia Stroke, May 1, 1997; 28(5): 1082 - 1085. [Abstract] [Full Text]
|
|