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AJNR - American Journal of Neuroradiology

American Journal of Neuroradiology, Vol 16, Issue 3 427-438, Copyright © 1995 by American Society of Neuroradiology

ARTICLES

Perinatal asphyxia: MR findings in the first 10 days

AJ Barkovich, K Westmark, C Partridge, A Sola and DM Ferriero
Department of Radiology, University of California San Francisco 94143- 0628, USA.

PURPOSE: To determine whether one can detect hypoxic-ischemic brain injury by MR in the first 10 days of life and to identify patterns of injury in affected neonates. METHODS: Standard T1- and T2-weighted MR sequences that were performed in the first 10 days of life in 20 patients who suffered hypoxia/ischemia in the intrapartum or neonatal periods were reviewed retrospectively. Images were evaluated for patterns of signal changes. RESULTS: Four patients had normal findings and were clinically healthy. The remaining 16 patients were divided into four groups based on pattern of injury: (a) primarily deep gray matter involvement; (b) primarily cortical involvement; (c) primarily periventricular white matter injury; and (d) mixed injury pattern. Two patients had appearances that suggested prepartum injury. T1 shortening was seen in injured tissue as early as 3 days after injury. T2 shortening did not appear until 6 or 7 days after injury. CONCLUSION: MR can show brain damage in asphyxiated neonates during the first 10 days of life and shows early appearances of several patterns of brain injury.

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