American Journal of Neuroradiology, Vol 16, Issue 6 1185-1192, Copyright © 1995 by American Society of Neuroradiology
ARTICLES |
Diffusion-weighted MR in experimental sustained seizures elicited with kainic acid
Y Nakasu, S Nakasu, S Morikawa, S Uemura, T Inubushi and J Handa
Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan.
PURPOSE: To investigate the early changes in diffusion-weighted MR images in the sustained limbic seizures. METHOD: Intraperitoneal injection of kainic acid was used to induce sustained limbic seizures in seven rats. The animals were investigated with serial 2.0-T MR imaging beginning immediately after kainic acid-induced seizures, and at 24 hours, 3 days, and 7 days after the kainic acid injection. Diffusion-weighted spin-echo and T2-weighted images and apparent diffusion coefficients were sequentially assessed and compared with histologic changes. The results were compared with eight control animals given buffered saline intraperitoneally. RESULTS: Diffusion- weighted MR images revealed an increase in signal intensity bilaterally in the amygdala and the piriform cortices immediately after the sustained seizures, whereas T2-weighted images did not show changes in signal intensity at this time. Both diffusion-weighted and T2-weighted images showed marked increase in signal intensities in these same areas 24 hours after kainic acid injection. The apparent diffusion coefficient values were significantly lower in the area of the amygdala and the piriform cortex immediately after and lower again 24 hours after the sustained seizures. The area of hyperintensity in diffusion- weighted images was concordant with the histologic distribution of neuronal pyknosis and neuropile vacuolation. CONCLUSION: Diffusion- weighted MR revealed focal abnormalities in the limbic system after 1 hour of sustained seizures induced with kainic acid, before changes on T2-weighted imaging. Diffusion-weighted MR is a potential method for studying the mechanisms of brain damage caused by sustained seizures.
This article has been cited by other articles:
 |
|
 |
|
  J.P. Karis and for the Expert Panel on Neurologic Imaging Epilepsy AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1222 - 1224. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Provenzale, D. P. Barboriak, K. VanLandingham, J. MacFall, D. Delong, and D. V. Lewis Hippocampal MRI Signal Hyperintensity After Febrile Status Epilepticus Is Predictive of Subsequent Mesial Temporal Sclerosis Am. J. Roentgenol., April 1, 2008; 190(4): 976 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kharatishvili, R. Immonen, O. Grohn, and A. Pitkanen Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis Brain, December 1, 2007; 130(12): 3155 - 3168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Hsu, W.-T. Lee, and C. Chang Multiparametric MRI evaluation of kainic acid-induced neuronal activation in rat hippocampus Brain, December 1, 2007; 130(12): 3124 - 3134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Engelhorn, A. Hufnagel, J. Weise, M. Baehr, and A. Doerfler Monitoring of Acute Generalized Status Epilepticus Using Multilocal Diffusion MR Imaging: Early Prediction of Regional Neuronal Damage AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Engelhorn, A. Doerfler, J. Weise, M. Baehr, M. Forsting, and A. Hufnagel Cerebral Perfusion Alterations during the Acute Phase of Experimental Generalized Status Epilepticus: Prediction of Survival By Using Perfusion-Weighted MR Imaging and Histopathology AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1563 - 1570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Eidt, E. J. Kendall, and A. Obenaus Neuronal and Glial Cell Populations in the Piriform Cortex Distinguished by Using an Approximation of q-Space Imaging after Status Epilepticus AJNR Am. J. Neuroradiol., August 1, 2004; 25(7): 1225 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Calistri, F. Caramia, F. Bianco, F. Fattapposta, F. Pauri, and L. Bozzao Visualization of Evolving Status Epilepticus with Diffusion and Perfusion MR Imaging AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 671 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Stadnik, P. Demaerel, R. R Luypaert, C. Chaskis, K. L. Van Rompaey, A. Michotte, and M. J. Osteaux Imaging Tutorial: Differential Diagnosis of Bright Lesions on Diffusion-weighted MR Images RadioGraphics, January 1, 2003; 23(1): e7 - e7. [Abstract] [Full Text]
|
|
|
|
|
|
D. J. Covarrubias, P. H. Luetmer, and N. G. Campeau Posterior Reversible Encephalopathy Syndrome: Prognostic Utility of Quantitative Diffusion-Weighted MR Images AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 1038 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Yoo, K.-H. Chang, I. C. Song, M. H. Han, B. J. Kwon, S. H. Lee, I. K. Yu, and C.-K. Chun Apparent Diffusion Coefficient Value of the Hippocampus in Patients with Hippocampal Sclerosis and in Healthy Volunteers AJNR Am. J. Neuroradiol., May 1, 2002; 23(5): 809 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-A. Kim, J. I. Chung, P. H. Yoon, D. I. Kim, T.-S. Chung, E.-J. Kim, and E.-K. Jeong Transient MR Signal Changes in Patients with Generalized Tonicoclonic Seizure or Status Epilepticus: Periictal Diffusion-weighted Imaging AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1149 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chu, D.-W. Kang, J.-Y. Kim, K.-H. Chang, and S. K. Lee Diffusion-Weighted Magnetic Resonance Imaging in Nonconvulsive Status Epilepticus Arch Neurol, June 1, 2001; 58(6): 993 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Eriksson, F. J. Rugg-Gunn, M. R. Symms, G. J. Barker, and J. S. Duncan Diffusion tensor imaging in patients with epilepsy and malformations of cortical development Brain, March 1, 2001; 124(3): 617 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Bronen The Status of Status: Seizures Are Bad for Your Brain's Health AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1782 - 1783. [Full Text] [PDF]
|
|
|
|
|
|
C. J. Wall, E. J. Kendall, and A. Obenaus Rapid Alterations in Diffusion-weighted Images with Anatomic Correlates in a Rodent Model of Status Epilepticus AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1841 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Schwartz, S. K. Feske, J. F. Polak, U. DeGirolami, A. Iaia, K. M. Beckner, S. M. Bravo, R. A. Klufas, R. Y. C. Chai, and J. T. Repke Preeclampsia-Eclampsia: Clinical and Neuroradiographic Correlates and Insights into the Pathogenesis of Hypertensive Encephalopathy Radiology, November 1, 2000; 217(2): 371 - 376. [Abstract] [Full Text]
|
|
|
|
|
|
H. Kassem-Moussa, J. M. Provenzale, J. R. Petrella, and D. V. Lewis Early Diffusion-Weighted MR Imaging Abnormalities in Sustained Seizure Activity Am. J. Roentgenol., May 1, 2000; 174(5): 1304 - 1306. [Full Text] [PDF]
|
|