American Journal of Neuroradiology, Vol 16, Issue 8 1711-1718, Copyright © 1995 by American Society of Neuroradiology
ARTICLES |
Spontaneous involution of optic pathway lesions in neurofibromatosis type 1: serial contrast MR evaluation
C Parazzini, F Triulzi, E Bianchini, V Agnetti, M Conti, C Zanolini, MM Maninetti, LN Rossi and G Scotti
Department of Neuroradiology, Scientific Institute H.S. Raffaele, University of Milan, Italy.
PURPOSE: To evaluate with contrast MR the evolution in size, signal, and contrast enhancement of optic pathway lesions in four patients with neurofibromatosis type 1. METHODS: The four reported patients are children with ages ranging from 21 months to 13 years affected by neurofibromatosis type 1 and optic pathway lesions. No treatment of the optic pathway lesions was carried out in these patients. They have been followed by serial contrast MR. RESULTS: In all patients a change in size, signal, and enhancement of optic pathways lesions was noted with time, and in the last follow-up study a marked reduction in size and enhancement of optic pathway lesions was observed in all cases. CONCLUSIONS: Modification and regression of optic pathway lesions with spontaneous disappearance of the enhancement is demonstrated. This finding could have a crucial influence on the therapeutic approach of the optic pathway lesions.
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