American Journal of Neuroradiology, Vol 17, Issue 5 859-863, Copyright © 1996 by American Society of Neuroradiology
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Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers
AB Anderson, TH Tran, MJ Hamilton, SJ Chudzik, BP Hastings, MJ Melchior and RW Hergenrother
BSI Corporation, Eden Prairie, Minn, USA.
The blood-contacting properties of polyethylene coated with a lubricious hydrophilic coating; an uncoated polyethylene; or a photoheparin-treated polyethylene-negative control sample were compared by measuring fibrinogen adsorption, antifibrinogen binding, and platelet attachment from human plasma. The polyethylene surfaces coated with a hydrophilic polymer were found to be similar to surfaces coated with heparin. Fibrinogen adsorption on the hydrophilic coating was 60% lower than adsorption on either the uncoated or heparin-coated polyethylene samples. Antifibrinogen binding from buffer to the hydrophilic coating was also reduced more than 85% from binding to uncoated polyethylene samples. Both the hydrophilic coating and heparin coating showed a reduction in platelet attachment by a factor of 100 over the uncoated sample as well as significantly reduced platelet activation.
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