American Journal of Neuroradiology, Vol 17, Issue 5 973-978, Copyright © 1996 by American Society of Neuroradiology
ARTICLES |
Deep gray matter structures in HIV infection: a proton MR spectroscopic study
DJ Meyerhoff, MW Weiner and G Fein
Department of Radiology, University of California, San Francisco, USA.
PURPOSE: To evaluate the effects of human immunodeficiency virus (HIV) infection on proton metabolites in brain regions carrying the heaviest HIV load. METHODS: We used two-dimensional proton MR spectroscopy with a preselected volume at the level of the third ventricle to measure N- acetyl-aspartate (NAA) and metabolites containing choline (Cho), and creatine (Cr) in the basal ganglia of eight cognitively impaired subjects who were seropositive for HIV and eight control subjects who were seronegative for HIV. Results are expressed as metabolite ratios. RESULTS: In the thalamus and lenticular nuclei, NAA/Cr was not different between the two groups. NAA/Cho was decreased in both the thalamus and lenticular nuclei of the HIV-positive group compared with the HIV-negative group. Cho/Cr tended to be increased in both the thalamus and lenticular nuclei of the HIV-positive group. CONCLUSIONS: The findings suggest no NAA differences between groups, consistent with negligible neuron loss in the region of the brain that carries the heaviest HIV load. The trends toward increased Cho/Cr are consistent with histopathologic findings of infiltration of subcortical gray matter structures with foamy macrophages, microglia, and lymphocytes, or possibly with gliosis.
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