American Journal of Neuroradiology, Vol 17, Issue 8 1451-1458, Copyright © 1996 by American Society of Neuroradiology
ARTICLES |
Arteriovenous malformation animal model for radiosurgery: the rete mirabile
AA De Salles, TD Solberg, P Mischel, TF Massoud, A Plasencia, S Goetsch, E De Souza and F Vinuela
Division of Neurosurgery, University of California at Los Angeles, School of Medicine, USA.
PURPOSE: To study the effects of single-dose radiation on the porcine rete mirabile, a tangle of microvessels that mimics human arteriovenous malformations of the brain. METHODS: Eight retia mirabilia received a single dose of radiation under stereotactic location with digital angiography and CT. The following doses were applied: 20, 30, 40, 50, 60, 70, 80, and 90 Gy. The animals were followed up for a period of 7 months. Findings at neurologic examination, serial angiography, and histopathologic examination were analyzed. RESULTS: Progressive occlusion as observed by angiography corresponded to the histopathologic finding of intimal hyperplasia; that is, marked thickening of the vessel wall, progressing to occlusion of the vascular lumen, and associated thrombosis. A direct dose response was noted for these changes. Neurologic findings were related to the dose distribution and to histologic findings in structures adjacent to the rete mirabile. CONCLUSION: The rete mirabile is an excellent model by which to study the radiologic and histologic effects of single-dose radiation to the microvasculature of the central nervous system.
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