American Journal of Neuroradiology, Vol 17, Issue 8 1485-1490, Copyright © 1996 by American Society of Neuroradiology
ARTICLES |
Proton MR spectroscopy of squamous cell carcinoma of the upper aerodigestive tract: in vitro characteristics
SK Mukherji, S Schiro, M Castillo, L Kwock, R Soper, W Blackstock, W Shockley and M Weissler
Department of Radiology, University of North Carolina, Chapel Hill, USA.
PURPOSE: To determine the ability of in vitro high-field-strength proton MR spectroscopy to differentiate squamous cell carcinoma of the upper aerodigestive tract from uninvolved muscle. METHODS: Surgical specimens of squamous cell carcinoma arising from the upper aerodigestive tract (n = 18) and from muscle (n = 13) were examined in vitro using high-field (11 T) proton MR spectroscopy. The peak heights of choline and creatine were measured for tumor and muscle at echo times of 136 and 272. The choline/creatine (Cho/Cr) ratio was compared between tumor and normal tissue for each echo time. Student's t test was used to determine whether a significant difference existed between proton MR spectroscopic measurements of the Cho/Cr ratio for tumor and muscle. RESULTS: The mean Cho/Cr ratio was consistently higher in tumor than in muscle at all echo times; however, statistically significant differences between tumor and muscle were identified only at longer echo times (136 and 272). CONCLUSION: The Cho/Cr peak height ratio can be used to differentiate tumor from muscle in vitro (at 11 T).
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