American Journal of Neuroradiology, Vol 17, Issue 8 1539-1547, Copyright © 1996 by American Society of Neuroradiology
ARTICLES |
Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: correlative findings of active versus irreversible plaque disease
H Kimura, RI Grossman, RE Lenkinski and F Gonzalez-Scarano
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
PURPOSE: To characterize plaques of multiple sclerosis (MS) using both proton MR spectroscopy and magnetization transfer (MT) imaging. METHODS: The magnetization transfer ratio (MTR) was calculated from two series of three-dimensional gradient-recalled acquisition in the steady state (GRASS) images obtained with and without an MT saturation pulse. Proton spectra were acquired using the point-resolved spectroscopy (PRESS) sequence with a voxel size of 1.5 x 1.5 x 1.5 cm3. A total of 28 spectra were obtained in 13 patients who had clinically definitive MS. The spectra were analyzed together with the MTR. RESULTS: A positive relationship was found between the N-acetylaspartate (NAA)/creatine (Cr) ratio and the MTR in MS plaques, whereas no significant correlation was found between the metabolite ratios and the signal intensity on fast spin-echo T2-weighted MR images. CONCLUSION: Small changes in the MTR of MS plaques relative to the MTR of normal white matter may reflect inflammatory changes and edema, whereas larger changes in MTR correlate with decreased NAA/Cr ratio and therefore suggest demyelination and irreversible damage from chronic MS plaques.
This article has been cited by other articles:
 |
|
 |
|
  Y. Ge, R. I. Grossman, J. S. Babb, J. He, and L. J. Mannon Dirty-Appearing White Matter in Multiple Sclerosis: Volumetric MR Imaging and Magnetization Transfer Ratio Histogram Analysis AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 1935 - 1940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. McFarland, F. Barkhof, J. Antel, and D. Miller The role of MRI as a surrogate outcome measure in multiple sclerosis Multiple Sclerosis, September 1, 2002; 8(1_suppl): 40 - 51. [Abstract] [PDF]
|
|
|
|
|
|
H F McFarland, F Barkhof, J Antel, and D H Miller The role of MRI as a surrogate outcome measure in multiple sclerosis Multiple Sclerosis, February 1, 2002; 8(1): 40 - 51. [Abstract] [PDF]
|
|
|
|
|
|
G. Sinson, L. J. Bagley, K. M. Cecil, M. Torchia, J. C. McGowan, R. E. Lenkinski, T. K. McIntosh, and R. I. Grossman Magnetization Transfer Imaging and Proton MR Spectroscopy in the Evaluation of Axonal Injury: Correlation with Clinical Outcome after Traumatic Brain Injury AJNR Am. J. Neuroradiol., January 1, 2001; 22(1): 143 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ropele, S. Strasser-Fuchs, M. Augustin, R. Stollberger, C. Enzinger, H.-P. Hartung, and F. Fazekas A Comparison of Magnetization Transfer Ratio, Magnetization Transfer Rate, and the Native Relaxation Time of Water Protons Related to Relapsing-remitting Multiple Sclerosis AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1885 - 1891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Mader, W. Roser, L. Kappos, G. Hagberg, J. Seelig, E. W. Radue, and W. Steinbrich Serial Proton MR Spectroscopy of Contrast-enhancing Multiple Sclerosis Plaques: Absolute Metabolic Values over 2 Years during a Clinical Pharmacological Study AJNR Am. J. Neuroradiol., July 1, 2000; 21(7): 1220 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P A Brex, G J M Parker, S M Leary, P D Molyneux, G J Barker, C A Davie, A J Thompson, and D H Miller Lesion heterogeneity in multiple sclerosis: a study of the relations between appearances on T1 weighted images, T1 relaxation times, and metabolite concentrations J. Neurol. Neurosurg. Psychiatry, May 1, 2000; 68(5): 627 - 632. [Abstract] [Full Text]
|
|
|
|
|
|
C A Davie, N C Silver, G J Barker, P S Tofts, A J Thompson, W I McDonald, and D H Miller Does the extent of axonal loss and demyelination from chronic lesions in multiple sclerosis correlate with the clinical subgroup? J. Neurol. Neurosurg. Psychiatry, December 1, 1999; 67(6): 710 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filippi, C. Tortorella, and M. Bozzali Normal-appearing white matter changes in multiple sclerosis: the contribution of magnetic resonance techniques Multiple Sclerosis, August 1, 1999; 5(4): 273 - 282. [Abstract] [PDF]
|
|
|
|
|
|
G. Pike, de Stefano, Narayanan, G. Francis, J. Antel, and D. Arnold Combined Magnetization Transfer and Proton Spectroscopic Imaging in the Assessment of Pathologic Brain Lesions in Multiple AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 829 - 837. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Ostuni, N. D. Richert, B. K. Lewis, and J. A. Frank Characterization of Differences between Multiple Sclerosis and Normal Brain: A Global Magnetization Transfer Application AJNR Am. J. Neuroradiol., March 1, 1999; 20(3): 501 - 507. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Miki, R. I. Grossman, J. K. Udupa, M. A. van Buchem, L. Wei, M. D. Phillips, U. Patel, J. C. McGowan, and D. L. Kolson Differences between Relapsing-Remitting and Chronic Progressive Multiple Sclerosis as Determined with Quantitative MR Imaging Radiology, March 1, 1999; 210(3): 769 - 774. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. D. Trapp, R. M. Ransohoff, E. Fisher, and R. A. Rudick Neurodegeneration in Multiple Sclerosis: Relationship to Neurological Disability Neuroscientist, January 1, 1999; 5(1): 48 - 57. [Abstract] [PDF]
|
|