American Journal of Neuroradiology, Vol 18, Issue 1 29-33, Copyright © 1997 by American Society of Neuroradiology
ARTICLES |
The nature of thrombosis induced by platinum and tungsten coils in saccular aneurysms
JV Byrne, JK Hope, N Hubbard and JH Morris
Department of Neuroradiology, Radcliffe Infirmary, Oxford, England.
PURPOSE: To compare the efficacy and biocompatability of electrolytic and mechanically detachable embolization coils of two metal types. METHODS: Experimental saccular aneurysms in pigs were used to assess embolization induced by platinum or tungsten coils. Longitudinal angiographic and histologic studies were performed on treated and untreated (control) aneurysms to compare thrombosis and cellular responses after embolization with electrolytically detachable platinum coils and with mechanically detached tungsten coils. RESULTS: Fewer tungsten than platinum coils were needed to induce thrombosis. The inflammatory response within the aneurysmal lumen was more florid in embolized aneurysms than in control aneurysms. No difference was found in the timing or extent of accumulation of eosinophils, lymphocytes, or polymorphs between the two coils used. Giant cell responses were more marked in treated aneurysms; tungsten coils more than platinum coils. The amount of collagen and fibrosis present increased over the study period and was similar in treated and control aneurysms. CONCLUSION: The coil type influenced the initial cellular response but had little effect on the rate or degree to which blood clot within the aneurysm was replaced by fibrous tissue.
This article has been cited by other articles:
 |
|
 |
|
  Y.H. Ding, D. Dai, D.A. Lewis, M.A. Danielson, R. Kadirvel, H.J. Cloft, and D.F. Kallmes Long-Term Patency of Elastase-Induced Aneurysm Model in Rabbits AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 139 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. I. Aviv, R. O'Neill, M. C. Patel, and I. R. Colquhoun Abciximab in Patients with Ruptured Intracranial Aneurysms AJNR Am. J. Neuroradiol., August 1, 2005; 26(7): 1744 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Raymond, I. Salazkin, A. Metcalfe, O. Robledo, G. Gevry, D. Roy, A. Weill, and F. Guilbert Lingual Artery Bifurcation Aneurysms for Training and Evaluation of Neurovascular Devices AJNR Am. J. Neuroradiol., September 1, 2004; 25(8): 1387 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sluzewski, W. J. van Rooij, M. J. Slob, J. O. Bescos, C. H. Slump, and D. Wijnalda Relation between Aneurysm Volume, Packing, and Compaction in 145 Cerebral Aneurysms Treated with Coils Radiology, June 1, 2004; 231(3): 653 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Raymond, A. Metcalfe, A.-C. Desfaits, E. Ribourtout, I. Salazkin, K. Gilmartin, G. Embry, and R. J. Boock Alginate for Endovascular Treatment of Aneurysms and Local Growth Factor Delivery AJNR Am. J. Neuroradiol., June 1, 2003; 24(6): 1214 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Raymond, F. Berthelet, A.-C. Desfaits, I. Salazkin, and D. Roy Cyanoacrylate Embolization of Experimental Aneurysms AJNR Am. J. Neuroradiol., January 1, 2002; 23(1): 129 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Padolecchia, G. Guglielmi, M. Puglioli, M. Castagna, V. Nardini, P. L. Collavoli, G. Guidetti, M. Dazzi, V. Zucchi, and P. Narducci Role of Electrothrombosis in Aneurysm Treatment with Guglielmi Detachable Coils: An In Vitro Scanning Electron Microscopic Study AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1757 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Piotin, S. Mandai, K. Sugiu, P. Gailloud, and D. A. Rüfenacht Endovascular Treatment of Cerebral Aneurysms: An In Vitro Study with Detachable Platinum Coils and Tricellulose Acetate Polymer Am. J. Roentgenol., January 1, 2001; 176(1): 235 - 239. [Abstract] [Full Text]
|
|
|
|
|
|
R. K. Lenthall, N. S. McConachie, and T. Jaspan Delayed Reconfiguration of a Guglielmi Detachable Coil Mass Associated with Late Occlusion of an Adjacent Aneurysm and Parent Vessel AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1908 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Piotin, S. Mandai, K. J. Murphy, K. Sugiu, P. Gailloud, J.-B. Martin, and D. A. Rüfenacht Dense Packing of Cerebral Aneurysms: An In Vitro Study with Detachable Platinum Coils AJNR Am. J. Neuroradiol., April 1, 2000; 21(4): 757 - 760. [Abstract] [Full Text]
|
|
|
|
 |
|
 A.-C. Desfaits, J. Raymond, and J. P. Muizelaar Growth Factors Stimulate Neointimal Cells In Vitro and Increase the Thickness of the Neointima Formed at the Neck of Porcine Aneurysms Treated by Embolization • Editorial Comment Stroke, February 1, 2000; 31(2): 498 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Strother INTERVENTIONAL NEURORADIOLOGY AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 19 - 24. [Full Text] [PDF]
|
|
|
|
|
|
C. Cognard, A. Weill, L. Spelle, M. Piotin, L. Castaings, A. Rey, and J. Moret Long-term Angiographic Follow-up of 169 Intracranial Berry Aneurysms Occluded with Detachable Coils Radiology, August 1, 1999; 212(2): 348 - 356. [Abstract] [Full Text]
|
|
|
|
|
|
J.V. Byrne Long-Term Outcomes of Guglielmi Detachable Coil Packing for Acutely Ruptured Cerebral Aneurysms AJNR Am. J. Neuroradiol., June 1, 1999; 20(6): 1184 - 1184. [Full Text]
|
|
|
|
|
|
M. Jeffree, J. Byrne, D. Royston, N. Deasy, and J. Morris The Porous, Guidewire-Directed, Detachable Aneurysm Liner: A New Concept in the Endovascular Treatment of Intracranial AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 774 - 779. [Abstract] [Full Text]
|
|