American Journal of Neuroradiology, Vol 18, Issue 10 1909-1914, Copyright © 1997 by American Society of Neuroradiology
ARTICLES |
Proton MR spectroscopy and neuropsychological testing in adrenoleukodystrophy
V Rajanayagam, M Balthazor, EG Shapiro, W Krivit, L Lockman and AE Stillman
Department of Radiology, University of Minnesota, Minneapolis 55455, USA.
PURPOSE: To determine early signs of disease in patients with childhood- onset cerebral adrenoleukodystrophy (COCALD) with the use of proton MR spectroscopy. METHODS: Eleven children with posterior COCALD involvement and three children with anterior COCALD involvement were studied with single-voxel proton MR spectroscopy and neuropsychological testing. Findings were compared with those in five healthy control subjects. RESULTS: Areas of abnormal T2 signal intensity in children with COCALD showed abnormal metabolite ratios relative to those of control subjects as follows: decreased N-acetylaspartate (NAA)/Creatine (Cr) and NAA/Choline (Ch) and increased Ch/Cr. Metabolite ratios from normal-appearing brain regions in the same patients also were abnormal, with reduced NAA/Cr and NAA/Ch and increased Ch/Cr values. The mean metabolite ratios in normal-appearing regions were between those in the abnormal regions and those found in the control subjects. Statistical comparison of these ratios with neuropsychological test scores, which are specific for anterior and posterior brain functions, showed a significant correlation with the abnormal metabolite ratios. Our results indicate that the normal-appearing brain regions in these patients are metabolically abnormal. CONCLUSION: Proton MR spectroscopy could be a useful noninvasive tool to evaluate extent of disease in patients with COCALD.
This article has been cited by other articles:
 |
|
 |
|
  P. L. Sah, R. Sharma, H. Kandpal, A. Seith, S. Rastogi, S. Bandhu, and N. R. Jagannathan In Vivo Proton Spectroscopy of Giant Cell Tumor of the Bone Am. J. Roentgenol., February 1, 2008; 190(2): W133 - W139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fatemi, S. A. Smith, P. Dubey, K. M. Zackowski, A. J. Bastian, P. C. van Zijl, H. W. Moser, G. V. Raymond, and X. Golay Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy Neurology, May 24, 2005; 64(10): 1739 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Barker and A. Horska Topical Review: Neuroimaging in Leukodystrophies J Child Neurol, August 1, 2004; 19(8): 559 - 570. [Abstract] [PDF]
|
|
|
|
 |
|
 W. Block, F. Jessen, F. Traber, S. Flacke, C. Manka, R. Lamerichs, E. Keller, R. Heun, and H. Schild Regional N-Acetylaspartate Reduction in the Hippocampus Detected With Fast Proton Magnetic Resonance Spectroscopic Imaging in Patients With Alzheimer Disease Arch Neurol, May 1, 2002; 59(5): 828 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Ball Jr PEDIATRIC NEURORADIOLOGY AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 29 - 36. [Full Text] [PDF]
|
|