American Journal of Neuroradiology, Vol 18, Issue 3 576-579, Copyright © 1997 by American Society of Neuroradiology
ARTICLES |
Intracranial vascular calcifications, glioblastoma multiforme, and lead poisoning
JG Teo, KY Goh, A Ahuja, HK Ng and WS Poon
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
A 72-year-man with previous lead poisoning presented with raised intracranial pressure and localizing neurologic signs. CT scans showed a high-grade glioma and extensive intracranial calcifications, which proved to be vascular in distribution on postmortem examination. The latter findings support the concept of dystrophic calcification following lead-induced cerebrovascular injury. Lead poisoning should be considered in the differential diagnosis of unexplained intracranial calcifications. There is also evidence from previous studies to suggest a causative relationship between lead poisoning and development of glioma.
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