American Journal of Neuroradiology, Vol 18, Issue 4 667-672, Copyright © 1997 by American Society of Neuroradiology
ARTICLES |
Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms
I Szikora, AK Wakhloo, LR Guterman, TD Chavis, RC Dawson 3rd, RW Hergenrother, RH Twyford and LN Hopkins
Stroke Research Institute, Department of Neurosurgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences 14209, USA.
PURPOSE: To evaluate the effectiveness of Guglielmi detachable coils (GDCs) filled with collagen threads in the permanent treatment of experimental aneurysms. METHODS: Seventeen side-wall aneurysms were surgically constructed in the canine common carotid artery; six were treated with conventional GDCs and 11 with collagen-filled GDCs. One aneurysms was removed at 1 week, the others were studied by digital subtraction angiography for a period of 8 to 12 weeks. Longitudinal sections of all aneurysms were examined by light microscopy. RESULTS: Angiograms obtained throughout the follow-up period showed no significant difference between aneurysms treated with conventional GDCs and those treated with collagen-filled GDCs. Light microscopy revealed a dense meshwork of newly formed collagen and fibroblasts near the collagen-filled GDCs, whereas a loose cellular meshwork surrounded the conventional GDCs at 8 and 12 weeks after treatment. CONCLUSION: Collagen threads within GDCs do not noticeably improve angiographic treatment of experimental aneurysms; however, these threads did induce local proliferation of fibroblasts and production of collagen within the aneurysmal cavities.
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