AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology, Vol 18, Issue 4 730-732, Copyright © 1997 by American Society of Neuroradiology


ARTICLES

CT demonstration of periorbital graft-versus-host disease

JW Cole, DJ Quint, RJ Hutchinson and GA Yanik
Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109, USA.

A 13-year-old boy who had undergone allogenic bone marrow transplantation for treatment of acute lymphocytic leukemia presented with bilateral periorbital rash and swelling. A CT scan showed bilateral symmetric periorbital swelling, subconjunctival fluid collections, and lacrimal gland enlargement. The patient was initially treated for presumed cellulitis. However, persistently negative regional cultures (eye, nasopharynx), a rapid response to immunosuppressive therapy after several days of nonresponse to intravenous antibiotic therapy, and ultimately, results of a skin biopsy confirmed the diagnosis of acute graft-versus-host disease.