American Journal of Neuroradiology, Vol 18, Issue 6 1087-1091, Copyright © 1997 by American Society of Neuroradiology
ARTICLES |
Hydrophilic coatings diminish adhesion of glue to catheter: an in vitro simulation of NBCA embolization
JM Mathis, AJ Evans, AJ DeNardo, K Kennett, JR Crandall, ME Jensen and JE Dion
Division of Neuroradiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
PURPOSE: To determine whether new hydrophilic microcatheter coatings exhibit characteristics that diminish the chance of permanent endovascular glue adhesion during liquid acrylic embolization. METHODS: Common hydrophilic and nonhydrophilic microcatheters (both flow- directed and over-the-wire) used in neurointerventional procedures were evaluated in vitro for liquid acrylic (Histoacryl and Avacryl)-to- catheter bond strength, catheter endovascular friction, and catheter stretch (tensile strength). Sufficient test repetitions were acquired to achieve statistical significance. RESULTS: The bond strength between hydrophilically coated catheters and NBCA was significantly weaker than between nonhydrophilic catheters and NBCA. Hydrophilic catheter coating reduced dynamic endovascular friction by 30% to 35%. All flow-directed catheters exhibited considerably more stretch (less tensile strength) and therefore were more prone to fracture during withdrawal than over- the-wire systems. Histoacryl bonded to both hydrophilic and nonhydrophilic catheters with a significantly greater force than did Avacryl. CONCLUSION: Hydrophilically coated catheters should be less likely to exhibit permanent endovascular fixation during acrylic embolization because of a weaker catheter-NBCA bond and because of reduced catheter friction (allowing a larger portion of any applied catheter withdrawal force to be transmitted to the catheter tip with less force dissipated along the catheter resulting in stretch). A significant difference in NBCA types (Histoacryl and Avacryl) was discovered: Avacryl developed a significantly weaker bond with all catheter types.
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