American Journal of Neuroradiology, Vol 18, Issue 8 1541-1547, Copyright © 1997 by American Society of Neuroradiology
ARTICLES |
Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements
Y Kato, K Matsumura, Y Kinosada, Y Narita, S Kuzuhara and T Nakagawa
Department of Neurology, Mie University School of Medicine, Japan.
PURPOSE: To determine the presence of small lesions in the pyramidal tract in patients with amyotrophic lateral sclerosis (ALS) by using magnetization-transfer (MT) measurements and MR imaging. METHODS: MT ratios (MTRs) were measured in the posterior limb of the internal capsule in nine patients with ALS and in nine healthy volunteers. RESULTS: The mean value of MTRs (%) in patients with ALS was 15.76 +/- 1.48, while that of the control subjects was 19.83 +/- 1.54. The difference was statistically significant. CONCLUSIONS: MT measurements are useful for detecting abnormalities associated with degeneration of the pyramidal tract in patients with ALS.
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