American Journal of Neuroradiology, Vol 19, Issue 1 143-149, Copyright © 1998 by American Society of Neuroradiology
ARTICLES |
Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems
AJ Barkovich, BL Hajnal, D Vigneron, A Sola, JC Partridge, F Allen and DM Ferriero
Department of Radiology, University of California, San Francisco, 94143, USA.
PURPOSE: We developed a scoring system for the assessment of perinatal asphyxia as depicted on MR images. METHODS: Four scoring systems were derived to evaluate MR images obtained in asphyxiated neonates: the basal ganglia (BG) score, the watershed (W) score, the combined basal ganglia/watershed (BG/W) score, and the sum of the BG and W scores, the summation (S) score. In addition, three MR sequences, T1-weighted, first-echo T2-weighted, and second-echo T2-weighted, were assessed for each patient for each scoring system. Neuromotor examinations were performed at ages 3 and 12 months, and cognitive development was tested at age 12 months. Statistical analysis was then performed to test the relationship between the MR scores and the outcome scores. RESULTS: The BG/W score, obtained with the first-echo T2-weighted sequence, was the most useful overall score for predicting neuromotor outcome at 3 and 12 months and cognitive outcome at 12 months. T1-weighted and first-echo T2-weighted sequences showed a stronger association with outcome in patients imaged during the first postnatal week, whereas second-echo T2- weighted sequences showed a stronger association with outcome in patients imaged during the second postnatal week. CONCLUSION: It appears that, with the use of the BG/W score, MR imaging discriminates accurately between patients with good and poor neuromotor and cognitive outcome at 3 and 12 months. In terms of our scoring systems, the first- echo T2-weighted sequence appears to discriminate best between patients with good and poor 3- and 12-month outcomes. Proper use of the imaging sequences and scoring systems described in this article can increase the knowledge base upon which treatment decisions are made in asphyxiated neonates.
This article has been cited by other articles:
 |
|
 |
|
  L. Liauw, J. van der Grond, A.A. van den Berg-Huysmans, L.A.E.M. Laan, M.A. van Buchem, and G. van Wezel-Meijler Is There a Way to Predict Outcome in (Near) Term Neonates with Hypoxic-Ischemic Encephalopathy Based on MR Imaging? AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1789 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Okereafor, J. Allsop, S. J. Counsell, J. Fitzpatrick, D. Azzopardi, M. A. Rutherford, and F. M. Cowan Patterns of Brain Injury in Neonates Exposed to Perinatal Sentinel Events Pediatrics, May 1, 2008; 121(5): 906 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Serrano, A. Ormazabal, B. Perez-Duenas, R. Artuch, W. Coroleu, X. Krauel, J. Campistol, and A. Garcia-Cazorla PERINATAL ASPHYXIA MAY CAUSE REDUCTION IN CSF DOPAMINE METABOLITE CONCENTRATIONS Neurology, July 17, 2007; 69(3): 311 - 313. [Full Text] [PDF]
|
|
|
|
|
|
A.I. Bartha, K.R.L. Yap, S.P. Miller, R.J. Jeremy, M. Nishimoto, D.B. Vigneron, A.J. Barkovich, and D.M. Ferriero The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1015 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shanmugalingam, J. S. Thornton, O. Iwata, A. Bainbridge, F. E. O'Brien, A. N. Priest, R. J. Ordidge, E. B. Cady, J. S. Wyatt, and N. J. Robertson Comparative Prognostic Utilities of Early Quantitative Magnetic Resonance Imaging Spin-Spin Relaxometry and Proton Magnetic Resonance Spectroscopy in Neonatal Encephalopathy Pediatrics, October 1, 2006; 118(4): 1467 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Boichot, P. M. Walker, C. Durand, M. Grimaldi, S. Chapuis, J. B. Gouyon, and F. Brunotte Term Neonate Prognoses after Perinatal Asphyxia: Contributions of MR Imaging, MR Spectroscopy, Relaxation Times, and Apparent Diffusion Coefficients Radiology, June 1, 2006; 239(3): 839 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tekgul, K. Gauvreau, J. Soul, L. Murphy, R. Robertson, J. Stewart, J. Volpe, B. Bourgeois, and A. J. du Plessis The Current Etiologic Profile and Neurodevelopmental Outcome of Seizures in Term Newborn Infants Pediatrics, April 1, 2006; 117(4): 1270 - 1280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.J. Barkovich, S.P. Miller, A. Bartha, N. Newton, S.E.G. Hamrick, P. Mukherjee, O.A. Glenn, D. Xu, J.C. Partridge, D.M. Ferriero, et al. MR Imaging, MR Spectroscopy, and Diffusion Tensor Imaging of Sequential Studies in Neonates with Encephalopathy AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 533 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shankaran, A. R. Laptook, R. A. Ehrenkranz, J. E. Tyson, S. A. McDonald, E. F. Donovan, A. A. Fanaroff, W. K. Poole, L. L. Wright, R. D. Higgins, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl. J. Med., October 13, 2005; 353(15): 1574 - 1584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-L. Khong, C. Tse, I. Y. C. Wong, B. C. C. Lam, P.-T. Cheung, W. H. S. Goh, Ngai Shan Kwong, and G.-C. Ooi Diffusion-Weighted Imaging and Proton Magnetic Resonance Spectroscopy in Perinatal Hypoxic-Ischemic Encephalopathy: Association With Neuromotor Outcome at 18 Months of Age J Child Neurol, November 1, 2004; 19(11): 872 - 881. [Abstract] [PDF]
|
|
|
|
|
|
R. W. Hunt, J. J. Neil, L. T. Coleman, M. J. Kean, and T. E. Inder Apparent Diffusion Coefficient in the Posterior Limb of the Internal Capsule Predicts Outcome After Perinatal Asphyxia Pediatrics, October 1, 2004; 114(4): 999 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ramaswamy, S. P. Miller, A. J. Barkovich, J. C. Partridge, and D. M. Ferriero Perinatal stroke in term infants with neonatal encephalopathy Neurology, June 8, 2004; 62(11): 2088 - 2091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Miller, P. S. McQuillen, D. B. Vigneron, D. V. Glidden, A. J. Barkovich, D. M. Ferriero, S. E. G. Hamrick, A. Azakie, and T. R. Karl Preoperative brain injury in newborns with transposition of the great arteries Ann. Thorac. Surg., May 1, 2004; 77(5): 1698 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Zarifi, L. G. Astrakas, T. Y. Poussaint, A. d. Plessis, D. Zurakowski, and A. A. Tzika Prediction of Adverse Outcome with Cerebral Lactate Level and Apparent Diffusion Coefficient in Infants with Perinatal Asphyxia Radiology, December 1, 2002; 225(3): 859 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Ment, H. S. Bada, P. Barnes, P. E. Grant, D. Hirtz, L. A. Papile, J. Pinto-Martin, M. Rivkin, and T. L. Slovis Practice parameter: Neuroimaging of the neonate: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society Neurology, June 25, 2002; 58(12): 1726 - 1738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Christophe, C. Fonteyne, F. Ziereisen, F. Christiaens, P. Deltenre, V. De Maertelaer, and B. Dan Value of MR Imaging of the Brain in Children with Hypoxic Coma AJNR Am. J. Neuroradiol., April 1, 2002; 23(4): 716 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Miller, J. Weiss, A. Barnwell, D. M. Ferriero, B. Latal-Hajnal, A. Ferrer-Rogers, N. Newton, J. C. Partridge, D. V. Glidden, D. B. Vigneron, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia Neurology, February 26, 2002; 58(4): 542 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Barkovich, K. D. Westmark, H. S. Bedi, J. C. Partridge, D. M. Ferriero, and D. B. Vigneron Proton Spectroscopy and Diffusion Imaging on the First Day of Life after Perinatal Asphyxia: Preliminary Report AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1786 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Wolf, R. A. Zimmerman, R. Clancy, and J. H. Haselgrove Quantitative Apparent Diffusion Coefficient Measurements in Term Neonates for Early Detection of Hypoxic-Ischemic Brain Injury: Initial Experience Radiology, March 1, 2001; 218(3): 825 - 833. [Abstract] [Full Text]
|
|
|
|
|
|
E. Biagioni, E. Mercuri, M. Rutherford, F. Cowan, D. Azzopardi, M. F. Frisone, G. Cioni, and L. Dubowitz Combined Use of Electroencephalogram and Magnetic Resonance Imaging in Full-Term Neonates With Acute Encephalopathy Pediatrics, March 1, 2001; 107(3): 461 - 468. [Abstract] [Full Text]
|
|
|
|
|
|
A. Coskun, M. Lequin, M. Segal, D. B. Vigneron, D. M. Ferriero, and A. J. Barkovich Quantitative Analysis of MR Images in Asphyxiated Neonates: Correlation with Neurodevelopmental Outcome AJNR Am. J. Neuroradiol., February 1, 2001; 22(2): 400 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. N. Forbes, J. G. Pipe, and R. Bird Neonatal Hypoxic-ischemic Encephalopathy: Detection with Diffusion-weighted MR Imaging AJNR Am. J. Neuroradiol., August 1, 2000; 21(8): 1490 - 1496. [Abstract] [Full Text]
|
|
|
|
|
|
E. Mercuri, D. Ricci, F. M. Cowan, D. Lessing, M. F. Frisone, L. Haataja, S. J. Counsell, L. M. Dubowitz, and M. A. Rutherford Head Growth in Infants With Hypoxic-Ischemic Encephalopathy: Correlation With Neonatal Magnetic Resonance Imaging Pediatrics, August 1, 2000; 106(2): 235 - 243. [Abstract] [Full Text]
|
|
|
|
|
|
L. T. L. Sie, M. S. van der Knaap, G. van Wezel-Meijler, A. H. M. Taets van Amerongen, H. N. Lafeber, and J. Valk Early MR Features of Hypoxic-ischemic Brain Injury in Neonates with Periventricular Densities on Sonograms AJNR Am. J. Neuroradiol., May 1, 2000; 21(5): 852 - 861. [Abstract] [Full Text]
|
|
|
|
|
|
W. S. Ball Jr PEDIATRIC NEURORADIOLOGY AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 29 - 36. [Full Text] [PDF]
|
|
|
|
|
|
A. J. Barkovich and D. M. Ferriero Line-Scan Diffusion Imaging of Term Neonates with Perinatal Brain Ischemia AJNR Am. J. Neuroradiol., October 1, 1999; 20(9): 1577 - 1579. [Full Text]
|
|
|
|
|
|
R. L. Robertson, L. Ben-Sira, P. D. Barnes, R. V. Mulkern, C. D. Robson, S. E. Maier, M. J. Rivkin, and A. J. d. Plessis MR Line-Scan Diffusion-Weighted Imaging of Term Neonates with Perinatal Brain Ischemia AJNR Am. J. Neuroradiol., October 1, 1999; 20(9): 1658 - 1670. [Abstract] [Full Text]
|
|
|
|
|
|
A. J. Barkovich, K. Baranski, D. Vigneron, J. C. Partridge, D. K. Hallam, B. L. Hajnal, and D. M. Ferriero Proton MR Spectroscopy for the Evaluation of Brain Injury in Asphyxiated, Term Neonates AJNR Am. J. Neuroradiol., September 1, 1999; 20(8): 1399 - 1405. [Abstract] [Full Text]
|
|
|
|
|
|
P. Jouvet, F. M. Cowan, P. Cox, E. Lazda, M. A. Rutherford, J. Wigglesworth, H. Mehmet, and A. D. Edwards Reproducibility and Accuracy of MR Imaging of the Brain after Severe Birth Asphyxia AJNR Am. J. Neuroradiol., August 1, 1999; 20(7): 1343 - 1348. [Abstract] [Full Text]
|
|