American Journal of Neuroradiology, Vol 19, Issue 1 95-99, Copyright © 1998 by American Society of Neuroradiology
ARTICLES |
MR of extraocular muscles in chronic progressive external ophthalmoplegia
TJ Carlow, MH Depper and WW Orrison Jr
Department of Radiology, the University of New Mexico, Albuquerque, USA.
PURPOSE: Our goal was to determine whether the extraocular muscles in patients with chronic progressive external ophthalmoplegia (CPEO) could be distinguished from those of age-matched control subjects by MR imaging. METHODS: Nine patients with CPEO and eight age-matched healthy control subjects were studied. The extraocular muscles of eight of the patients (16 eyes) and all the control subjects (16 eyes) were measured digitally. Images consisted of 1.5-mm contiguous sections acquired using a volume (three-dimensional) gradient-echo acquisition. In all, measurements were performed on 11 interpolated 1.0-mm coronal sections, five on each side of the muscle center. Only the medial, inferior, and lateral rectus muscles were evaluated. The superior rectus was omitted to avoid averaging problems with the superior ophthalmic vein and levator palpebrae muscle. The 11 sections were summed to obtain a volume measurement of the central portion of each muscle. RESULTS: The digitally measured extraocular muscles in the patients with CPEO had statistically significantly smaller volumes than those of the control subjects. The average muscle volumes for the patients with CPEO were 215 mm3 for the medial rectus, 202 mm3 for the inferior rectus, and 269 mm3 for the lateral rectus. The average extraocular muscle volumes for the control subjects were 366 mm3 for the medial rectus, 365 mm3 for the inferior rectus, and 425 mm3 for the lateral rectus. CONCLUSION: MR imaging can show small extraocular muscles in patients with CPEO, which may help to distinguish this disorder from other entities. Since denervated extraocular muscles do not readily atrophy, this MR sign would support a myogenic pathologic substrate for CPEO. Variation in the degree of extraocular muscle atrophy may simply reflect the length of time the mitochondrial defect and ophthalmoplegia have been present.
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  J. O. Heidenreich, T. Klopstock, T. Schirmer, P. Saemann, W. Mueller-Felber, and D. P. Auer Chronic progressive external ophthalmoplegia: MR spectroscopy and MR diffusion studies in the brain. Am. J. Roentgenol., September 1, 2006; 187(3): 820 - 824. [Abstract] [Full Text] [PDF]
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