American Journal of Neuroradiology, Vol 19, Issue 10 1897-1899, Copyright © 1998 by American Society of Neuroradiology
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Multifocal varicella-zoster virus leukoencephalitis in a patient with AIDS: MR findings
N Aygun, DA Finelli, MS Rodgers and RH Rhodes
Department of Radiology, MetroHealth Medical Center/Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA.
We describe a patient with AIDS who presented with an acute encephalitis caused by infection with varicella-zoster virus. The hemorrhagic, necrotizing encephalitis had an unusual MR appearance, with innumerable discrete, small, targetlike lesions in the right cerebral hemisphere, which were coalescent in the posterior temporal, parietal, and occipital regions. Of the several known disease patterns of varicella-zoster viral infection in the CNS, this histopathologic pattern of multifocal leukoencephalitis is rare. It is important to recognize, as effective antiviral drug treatments are available.
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