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American Journal of Neuroradiology, Vol 19, Issue 2 383-385, Copyright © 1998 by American Society of Neuroradiology

ARTICLES

Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy

SG Pavlakis, D Lu, Y Frank, A Wiznia, D Eidelberg, T Barnett and RA Hyman
Department of Neurology, New York University School of Medicine, North Shore University Hospital, Manhasset 11030, USA.

Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate (NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvement in NAA/Cr and an absence of the abnormal lactate peak. We suggest that decreased NAA/Cr in AIDS is reversible, that brain lactate might correlate with inflammation, and that MR spectroscopy can be useful in treatment trials.


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Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X