American Journal of Neuroradiology, Vol 19, Issue 3 415-417, Copyright © 1998 by American Society of Neuroradiology
ARTICLES |
Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome
Y Ito, Y Arahata, Y Goto, M Hirayama, M Nagamutsu, T Yasuda, T Yanagi and G Sobue
Department of Neurology, Nagoya University School of Medicine, Japan.
Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper- limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs. Our patient also had hypomagnesemia, which may have figured in the pathophysiology.
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