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American Journal of Neuroradiology, Vol 19, Issue 3 485-487, Copyright © 1998 by American Society of Neuroradiology

ARTICLES

Acquired hepatocerebral degeneration: MR and pathologic findings

J Lee, D Lacomis, S Comu, J Jacobsohn and E Kanal
Department of Radiology, University of Pittsburgh School of Medicine, PA 15213, USA.

Acquired (non-Wilsonian) hepatocerebral degeneration (AHD) is a rare irreversible neurologic syndrome that occurs in patients with chronic liver disease associated with multiple metabolic insults. The pathophysiology and the locations of the cerebral injuries are incompletely understood. We describe a patient with fatal hepatic cirrhosis and AHD in whom MR images showed abnormalities in the brachium pontis bilaterally. Neuropathologic evaluation disclosed multiple regions of subcortical spongiform white matter changes.


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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X