American Journal of Neuroradiology, Vol 19, Issue 3 535-540, Copyright © 1998 by American Society of Neuroradiology
REVIEWS |
Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas
JH Hwang, GF Egnaczyk, E Ballard, RS Dunn, SK Holland and WS Ball Jr
Imaging Research Center, Department of Radiology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
PURPOSE: We report the common characteristics of juvenile pilocytic astrocytomas revealed by proton MR spectroscopy. METHODS: Eight children with pilocytic astrocytomas were studied with proton MR spectroscopy. The selected sampling volume was approximately 4 cm3, obtained from solid tumor. To localize the sampling volume, we used point-resolved spectroscopy (PRESS) and stimulated-echo acquisition mode (STEAM) techniques to acquire long- and short-TE spectra, respectively. Spectra from PRESS and STEAM sequences were processed using Lorentzian-to-Gaussian transformation and exponential apodization, respectively. For PRESS (2000/270) spectra, peaks of creatine, choline, N-acetylaspartate (NAA), and lactate resonances were integrated; for STEAM (2000/20) spectra, we measured the amplitude of the peaks at 3.2, 2.0, 1.3 and 0.9 ppm. RESULTS: An elevated lactate doublet was observed in the PRESS spectra. The choline/NAA ratio was 3.40. The amplitude ratios of the lipid pattern (0.9, 1.3 and 2.0 ppm) to choline were all below one. CONCLUSION: Despite the benign histology of the tumor, which generally lacks necrosis, a lactate signal was detected in all eight patients studied. A dominant lipid pattern was not observed.
This article has been cited by other articles:
 |
|
 |
|
  L.L. Linscott, A.G. Osborn, S. Blaser, M. Castillo, R.H. Hewlett, N. Wieselthaler, S.S. Chin, J. Krakenes, G.L. Hedlund, and C.L. Sutton Pilomyxoid Astrocytoma: Expanding the Imaging Spectrum AJNR Am. J. Neuroradiol., November 1, 2008; 29(10): 1861 - 1866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Al-Okaili, J. Krejza, J. H. Woo, R. L. Wolf, D. M. O'Rourke, K. D. Judy, H. Poptani, and E. R. Melhem Intraaxial Brain Masses: MR Imaging-based Diagnostic Strategy--Initial Experience Radiology, May 1, 2007; 243(2): 539 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Panigrahy, M.D. Krieger, I. Gonzalez-Gomez, X. Liu, J.G. McComb, J.L. Finlay, M.D. Nelson Jr., F.H. Gilles, and S. Bluml Quantitative Short Echo Time 1H-MR Spectroscopy of Untreated Pediatric Brain Tumors: Preoperative Diagnosis and Characterization AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 560 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Koeller and E. J. Rushing From the Archives of the AFIP: Pilocytic Astrocytoma: Radiologic-Pathologic Correlation RadioGraphics, November 1, 2004; 24(6): 1693 - 1708. [Abstract] [Full Text] [PDF]
|
|