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American Journal of Neuroradiology, Vol 19, Issue 4 648-652, Copyright © 1998 by American Society of Neuroradiology

ARTICLES

Progressive brain failure after diffuse hypoxic ischemic brain injury: a serial MR and proton MR spectroscopic study

A Falini, AJ Barkovich, G Calabrese, D Origgi, F Triulzi and G Scotti
Department of Neuroradiology, Scientific Institute San Raffaele Hospital, University of Milan, Italy.

The findings at sequential MR imaging and proton MR spectroscopy of a patient with profound hypoxic-ischemic brain injury are reported. The pattern of structural and biochemical changes observed closely reflected the known evolution of postasphyxic brain degeneration. Particularly noteworthy were the sharp decrease of cortical N- acetylaspartate in the acute phase, suggesting the severity of the neuronal insult, and the subsequent progressive increase of choline, paralleling the delayed degeneration of white matter.




Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X