American Journal of Neuroradiology 20:139-144 (1 1999)
© 1999 American Society of Neuroradiology
ARTICLE
Comparative MR Analysis of the Entorhinal Cortex and Hippocampus in Diagnosing Alzheimer Disease
a From the Department of Neuroscience and Neurology (K.J., M.P.L., H.S.), University of Kuopio; and the Departments of Neurology (H.S.) and Radiology (M.P.L., K.P.), Kuopio University Hospital, Kuopio, Finland.
BACKGROUND AND PURPOSE: Our purpose was to use volumetric MR imaging to compare the extent of atrophy and discriminative ability of the volumes of two temporal lobe structures, the entorhinal cortex and the hippocampus, between patients with Alzheimer disease and control subjects.
METHODS: The study group consisted of 30 patients with probable Alzheimer disease diagnosed according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria and 32 healthy control subjects. The MR volumes of the entorhinal cortex and the hippocampus were used for the discriminant function and receiver operator characteristic analysis as well as multivariate analysis of variance for repeated measures to compare their discriminative power.
RESULTS: Compared with control subjects, patients with Alzheimer disease had significantly smaller volumes of the entorhinal cortex and the hippocampus on both sides. Both the receiver operator characteristic and the discriminant function analyses using both volumes classified control subjects and Alzheimer patients with a high degree of accuracy (approximately 90%). Significant group x region interaction favoring hippocampal volumetry was determined by multivariate analysis of variance.
CONCLUSION: The volumetric measurements of both the entorhinal cortex and hippocampus have comparably high discriminative power in diagnosing Alzheimer disease. In clinical practice, hippocampal volumetry may be more feasible, because the method is easier to use and has less variability.
This article has been cited by other articles:
 |
|
 |
|
  O. Colliot, G. Chetelat, M. Chupin, B. Desgranges, B. Magnin, H. Benali, B. Dubois, L. Garnero, F. Eustache, and S. Lehericy Discrimination between Alzheimer Disease, Mild Cognitive Impairment, and Normal Aging by Using Automated Segmentation of the Hippocampus Radiology, July 1, 2008; 248(1): 194 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Hu, G. Qian, M. Teistler, and S. Huang Informatics in Radiology: Automatic and Adaptive Brain Morphometry on MR Images RadioGraphics, March 1, 2008; 28(2): 345 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.H. Ridha, M.R. Symms, D.J. Tozer, K.C. Stockton, C. Frost, M.M. Siddique, E.B. Lewis, D.G. MacManus, P.A. Boulby, G.J. Barker, et al. Magnetization Transfer Ratio in Alzheimer Disease: Comparison with Volumetric Measurements AJNR Am. J. Neuroradiol., May 1, 2007; 28(5): 965 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. F. Jones, J. Barnes, H. B.M. Uylings, N. C. Fox, C. Frost, M. P. Witter, and P. Scheltens Differential Regional Atrophy of the Cingulate Gyrus in Alzheimer Disease: A Volumetric MRI Study Cereb Cortex, December 1, 2006; 16(12): 1701 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ramani, J. H. Jensen, and J. A. Helpern Quantitative MR Imaging in Alzheimer Disease Radiology, October 1, 2006; 241(1): 26 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.L. Giesel, H.K. Hahn, P.A. Thomann, E. Widjaja, E. Wignall, H. von Tengg-Kobligk, J. Pantel, P.D. Griffiths, H.O. Peitgen, J. Schroder, et al. Temporal Horn Index and Volume of Medial Temporal Lobe Atrophy Using a New Semiautomated Method for Rapid and Precise Assessment AJNR Am. J. Neuroradiol., August 1, 2006; 27(7): 1454 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Lerch, J. C. Pruessner, A. Zijdenbos, H. Hampel, S. J. Teipel, and A. C. Evans Focal Decline of Cortical Thickness in Alzheimer's Disease Identified by Computational Neuroanatomy Cereb Cortex, July 1, 2005; 15(7): 995 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Stoub, M. Bulgakova, S. Leurgans, D. A. Bennett, D. Fleischman, D. A. Turner, and L. deToledo-Morrell MRI predictors of risk of incident Alzheimer disease: A longitudinal study Neurology, May 10, 2005; 64(9): 1520 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fernandez, J. Arrazola, F. Maestu, C. Amo, P. Gil-Gregorio, C. Wienbruch, and T. Ortiz Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease: Volumetric MR Imaging-Magnetoencephalographic Study AJNR Am. J. Neuroradiol., March 1, 2003; 24(3): 481 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Neugroschl and K. L. Davis Biological Markers in Alzheimer Disease Am J Geriatr Psychiatry, December 1, 2002; 10(6): 660 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Du, N. Schuff, M. P. Laakso, X. P. Zhu, W. J. Jagust, K. Yaffe, J. H. Kramer, B. L. Miller, B. R. Reed, D. Norman, et al. Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus Neurology, June 11, 2002; 58(11): 1635 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Scahill, J. M. Schott, J. M. Stevens, M. N. Rossor, and N. C. Fox Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI PNAS, April 2, 2002; 99(7): 4703 - 4707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Bigler, C. V. Andersob, and D. D. Blatter Temporal Lobe Morphology in Normal Aging and Traumatic Brain Injury AJNR Am. J. Neuroradiol., February 1, 2002; 23(2): 255 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Frisoni, C. Geroldi, A. Beltramello, A. Bianchetti, G. Binetti, G. Bordiga, C. DeCarli, M. P. Laakso, H. Soininen, C. Testa, et al. Radial Width of the Temporal Horn: A Sensitive Measure in Alzheimer Disease AJNR Am. J. Neuroradiol., January 1, 2002; 23(1): 35 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Cohen, C. Small, F. Lalonde, J. Friz, and T. Sunderland Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women Neurology, December 26, 2001; 57(12): 2223 - 2228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A T Du, N Schuff, D Amend, M P Laakso, Y Y Hsu, W J Jagust, K Yaffe, J H Kramer, B Reed, D Norman, et al. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, October 1, 2001; 71(4): 441 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sencakova, N. R. Graff-Radford, F. B. Willis, J. A. Lucas, F. Parfitt, R. H. Cha, P. C. O'Brien, R. C. Petersen, and C. R. Jack Jr Hippocampal Atrophy Correlates With Clinical Features of Alzheimer Disease in African Americans Arch Neurol, October 1, 2001; 58(10): 1593 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kato, D. Knopman, and H. Liu Dissociation of regional activation in mild AD during visual encoding: A functional MRI study Neurology, September 11, 2001; 57(5): 812 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Hsu, A.-T. Du, N. Schuff, and M. W. Weiner Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Dementias J Geriatr Psychiatry Neurol, September 1, 2001; 14(3): 145 - 166. [Abstract] [PDF]
|
|
|
|
|
|
A Colchester, D Kingsley, D Lasserson, B Kendall, F Bello, C Rush, T G Stevens, G Goodman, G Heilpern, N Stanhope, et al. Structural MRI volumetric analysis in patients with organic amnesia, 1: methods and comparative findings across diagnostic groups J. Neurol. Neurosurg. Psychiatry, July 1, 2001; 71(1): 13 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de Leon, M. Bobinski, A. Convit, O. Wolf, R. Insausti, C. R. Jack Jr., Y. Xu, and R. C. Petersen Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD Neurology, March 27, 2001; 56(6): 820 - 823. [Full Text] [PDF]
|
|
|
|
|
|
L.-O. Wahlund, P. Julin, S.-E. Johansson, and P. Scheltens Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study J. Neurol. Neurosurg. Psychiatry, November 1, 2000; 69(5): 630 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Bigler, C. M. Lowry, C. V. Anderson, S. C. Johnson, J. Terry, and M. Steed Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1857 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hanyu, T. Asano, T. Iwamoto, M. Takasaki, H. Shindo, and K. Abe Magnetization Transfer Measurements of the Hippocampus in Patients with Alzheimer's Disease, Vascular Dementia, and Other Types of Dementia AJNR Am. J. Neuroradiol., July 1, 2000; 21(7): 1235 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, C. R. Jack Jr., P. C. O'Brien, E. Kokmen, G. E. Smith, R. J. Ivnik, B. F. Boeve, R. G. Tangalos, and R. C. Petersen Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD Neurology, May 9, 2000; 54(9): 1760 - 1767. [Abstract] [Full Text] [PDF]
|
|