AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murayama, Y.
Right arrow Articles by Abe, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murayama, Y.
Right arrow Articles by Abe, T.

ARTICLE

Development of the Biologically Active Guglielmi Detachable Coil for the Treatment of Cerebral Aneurysms. Part II: An Experimental Study in a Swine Aneurysm Model

Yuichi Murayama,a, Fernando Viñuelaa, Yoshiaki Suzukia, Yoichi Akibaa, Alex Ulihoaa, Gary R. Duckwilera, Y. Pierre Gobina, Harry V. Vintersa, Masaya Iwakia and Toshiaki Abea

a From the Division of Interventional Neuroradiology, Leo G. Rigler Radiological Research Center (Y.M., F.V., Y.A., A.U., G.R.D., Y.P.G.), and Division of Neuropathology (H.V.V.), University of California, Los Angeles, School of Medicine; Department of Neurosurgery (Y.M., T.A., Y.A.), the Jikei University School of Medicine, Tokyo Japan; and The Institute of Physical and Chemical Research (Y.S., M.I.), Wako, Saitama, Japan.

BACKGROUND AND PURPOSE: Ion implantation is a surface-modification technology that creates a borderless surface on protein-coated platinum; this change in physical and chemical properties on the surface of Guglielmi detachable coils (GDCs) appears to enhance cell proliferation and adhesion. Our purpose was to evaluate the effect of ion implantation on GDCs in an experimental aneurysm model.

METHODS: GDCs were coated with either type I collagen, fibronectin, vitronectin, laminin, or fibrinogen. Using He+ or Ne+ 1 x 1014–15 ions/cm2, ion implantation was performed on these protein-coated GDCs (GDC-Is). A total of 56 experimental aneurysms were constructed microsurgically in the common carotid arteries of 28 swine. These experimental aneurysms were embolized with standard GDCs (n = 23), collagen GDC-Is (n = 11), vitronectin GDC-Is (n = 6), laminin GDC-Is (n = 4), fibrinogen GDC-Is (n = 6), and fibronectin GDC-Is (n = 6). The animals were sacrificed at day 14 after coil embolization. The physical properties of the new coils (friction on delivery, deployment into aneurysms, trackability, etc) and the development of tissue scarring and neoendothelium across the aneurysm's orifice were evaluated macroscopically and microscopically.

RESULTS: No evidence of increased coil friction/stiffness was observed during delivery of GDC-Is through microcatheters in this aneurysm model. A more intense scar formation and neoendothelium at the neck of aneurysms were observed macroscopically when treated with GDC-Is. Significant differences in the proportion of neck coverage between standard GDCs (48.3% ± 20.5%) and all GDC-I groups were observed (collagen GDC-I—89.4% ± 14.9%, P < .01; vitronectin GDC-I—71.5% ± 7.0%, P < .05; laminin GDC-I—76.5% ± 11.0%, P < .05; fibrinogen GDC-I—74.8% ± 13.9%, P < .05; fibronectin GDC-I—87.5% ± 15.0%, P < .01). Light microscopy showed a well-organized fibrous tissue bridging the aneurysm's neck when using GDC-Is, whereas only a fibrin-like thin layer covered the standard GDC surfaces.

CONCLUSION: GDC-Is indicated a more intense inflammatory response in the aneurysm body and dome and faster re-endothelial coverage of the neck of the aneurysm. This accelerated histologic response may decrease the chances of coil compaction and aneurysm recanalization. This technology may improve anatomic and clinical outcomes in patients harboring intracranial aneurysms.




This article has been cited by other articles:


Home page
Am. J. Neuroradiol.Home page
C.T. Whitlow, C.P. Geer, C.W.T. Mattern, B.J. Mussat-Whitlow, S.K. Yazdani, J.L. Berry, J.H. Lalli, R.O. Claus, V.R. Challa, and P.P. Morris
Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation
AJNR Am. J. Neuroradiol., January 1, 2009; 30(1): 85 - 90.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
T. Tsumoto, J.K. Song, Y. Niimi, and A. Berenstein
Interval Change in Size of Venous Pouch Canine Bifurcation Aneurysms over a 10-Month Period
AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1067 - 1070.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
D.J. Rivet, C.J. Moran, A. Mazumdar, T.K. Pilgram, C.P. Derdeyn, and D.T. Cross
Single-Institution Experience with Matrix Coils in the Treatment of Intracranial Aneurysms: Comparison with Same-Center Outcomes with the Use of Platinum Coils
AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1736 - 1742.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
R. Kadirvel, D. Dai, Y.H. Ding, M.A. Danielson, D.A. Lewis, H.J. Cloft, and D.F. Kallmes
Endovascular Treatment of Aneurysms: Healing Mechanisms in a Swine Model Are Associated with Increased Expression of Matrix Metalloproteinases, Vascular Cell Adhesion Molecule-1, and Vascular Endothelial Growth Factor, and Decreased Expression of Tissue Inhibitors of Matrix Metalloproteinases
AJNR Am. J. Neuroradiol., May 1, 2007; 28(5): 849 - 856.
[Abstract] [Full Text] [PDF]


Home page
J. Neurol. Neurosurg. PsychiatryHome page
N Pouratian, R J Oskouian Jr, M E Jensen, N F Kassell, and A S Dumont
Endovascular management of unruptured intracranial aneurysms
J. Neurol. Neurosurg. Psychiatry, May 1, 2006; 77(5): 572 - 578.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
I. Szikora, P. Seifert, Z. Hanzely, Z. Kulcsar, Z. Berentei, M. Marosfoi, S. Czirjak, J. Vajda, and I. Nyary
Histopathologic evaluation of aneurysms treated with guglielmi detachable coils or matrix detachable microcoils.
AJNR Am. J. Neuroradiol., February 1, 2006; 27(2): 283 - 288.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
D. Dai, Y. H. Ding, M. A. Danielson, R. Kadirvel, D. A. Lewis, H. J. Cloft, and D. F. Kallmes
Histopathologic and Immunohistochemical Comparison of Human, Rabbit, and Swine Aneurysms Embolized with Platinum Coils
AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2560 - 2568.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
I. Linfante, N. M. Akkawi, A. Perlow, V. Andreone, and A. K. Wakhloo
Polyglycolide/Polylactide-Coated Platinum Coils for Patients With Ruptured and Unruptured Cerebral Aneurysms: A Single-Center Experience
Stroke, September 1, 2005; 36(9): 1948 - 1953.
[Abstract] [Full Text] [PDF]


Home page
RadiologyHome page
M. Sluzewski, W. J. van Rooij, M. J. Slob, J. O. Bescos, C. H. Slump, and D. Wijnalda
Relation between Aneurysm Volume, Packing, and Compaction in 145 Cerebral Aneurysms Treated with Coils
Radiology, April 29, 2004; (2004) 2313030460.
[Abstract] [Full Text]


Home page
StrokeHome page
Y. Murayama, S. Tateshima, N. R. Gonzalez, and F. Vinuela
Matrix and Bioabsorbable Polymeric Coils Accelerate Healing of Intracranial Aneurysms: Long-Term Experimental Study
Stroke, August 1, 2003; 34(8): 2031 - 2037.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
D. F. Kallmes, N. H. Fujiwara, D. Yuen, D. Dai, and S.-T. Li
A Collagen-Based Coil for Embolization of Saccular Aneurysms in a New Zealand White Rabbit Model
AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 591 - 596.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
D. F. Kallmes and N. H. Fujiwara
New Expandable Hydrogel-Platinum Coil Hybrid Device for Aneurysm Embolization
AJNR Am. J. Neuroradiol., October 1, 2002; 23(9): 1580 - 1588.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
T. Abruzzo, H. J. Cloft, M. Marek, G. G. Shengelaia, P. B. Snowhill, S. M. Waldrop, and A. Sambanis
Interaction of Vascular Smooth Muscle Cells with Collagen-Impregnated Embolization Coils Studied with a Novel Quantitative in Vitro Model
AJNR Am. J. Neuroradiol., April 1, 2002; 23(4): 674 - 681.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
Y. Murayama, F. Vinuela, S. Tateshima, N. R. Gonzalez, J. K. Song, H. Mahdavieh, and L. Iruela-Arispe
Cellular Responses of Bioabsorbable Polymeric Material and Guglielmi Detachable Coil in Experimental Aneurysms
Stroke, April 1, 2002; 33(4): 1120 - 1128.
[Abstract] [Full Text] [PDF]