Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chaloupka, J. C. Articles by Vinters, H. V. Search for Related Content PubMed PubMed Citation Articles by Chaloupka, J. C. Articles by Vinters, H. V.

American Journal of Neuroradiology 20:401-410 (3 1999)
© 1999 American Society of Neuroradiology

ARTICLE

A Reexamination of the Angiotoxicity of Superselective Injection of DMSO in the Swine Rete Embolization Model^,

John C. Chaloupka^,a, Daniel C. Huddle^a, Jonathan Alderman^a, Stanley Fink^a, Robert Hammond^a and Harry V. Vinters^a

^a From the Departments of Diagnostic Radiology (J.C.C., D.C.H., J.A.) and Neurosurgery (J.C.C.), Yale University School of Medicine; Clinical Research Consultant, MicroTherapeutics, Inc, San Clemente, CA (S.F.); the Department of Pathology, London Health Sciences Centre (R.H.); and the Department of Pathology, UCLA School of Medicine (H.V.V.).

BACKGROUND AND PURPOSE: There are a variety of embolization applications for nonadhesive, liquid agents. We reevaluated the potential microvascular angiotoxicity of superselective infusions of dimethyl sulfoxide (DMSO) using very long infusion rates in a previously described animal model.

METHODS: Twenty-six swine underwent percutaneous femoral puncture for superselective catheterization of the artery of the rete while being continuously monitored for ECG and intraarterial pressure. Two volumes (0.5 or 0.8 mL) and three durations (30, 60, and 90 seconds) of superselective infusion of DMSO were used to evaluate the effect of a single-dose rate within an ipsilateral rete. Contralateral control infusions of normal saline were also administered. Acute hemodynamic and angiographic outcomes were assessed. After recovery, follow-up angiography and sacrifice were performed at either 10 or 28 days. Brains and retia were harvested for gross and microscopic histopathologic evaluation.

RESULTS: No significant hemodynamic alterations occurred acutely. Twenty-three of the 24 infused retia showed variable acute vasospasm that typically was mild to moderate in severity and transient (10 to 20 minutes). Follow-up angiography at sacrifice always showed normal retial arterial anatomy. No adverse clinical sequelae were noted. Gross inspection of brains showed no evidence of infarction or subarachnoid hemorrhage. Microscopic histopathologic examination of retia showed mostly nonspecific changes in both exposed and control samples. Possible causal histotoxicity was seen in four retia (three of four exposed to higher dose rates), in which involvement was limited to one to three retial arteries.

CONCLUSION: Lower total dose and dose rates of superselective infusion of DMSO into the retial microarterial network resulted in substantially less angiotoxicity than that found in a previous study, as defined by clinical, angiographic, gross, and histopathologic criteria.

This article has been cited by other articles:

				Z. K. Otrock, A. Beydoun, W. M. Barada, R. Masroujeh, R. Hourani, and A. Bazarbachi Transient global amnesia associated with the infusion of DMSO-cryopreserved autologous peripheral blood stem cells Haematologica, March 1, 2008; 93(3): e36 - e37. [Abstract] [Full Text] [PDF]

				A. S. Chen-Plotkin, K. A. Vossel, M. A. Samuels, and M. H. Chen Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation Neurology, March 13, 2007; 68(11): 859 - 861. [Abstract] [Full Text] [PDF]

				W. Weber, B. Kis, R. Siekmann, and D. Kuehne Endovascular Treatment of Intracranial Arteriovenous Malformations with Onyx: Technical Aspects AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 371 - 377. [Abstract] [Full Text] [PDF]

				O. Dudeck, O. Jordan, K.T. Hoffmann, A.F. Okuducu, I. Husmann, T. Kreuzer-Nagy, K. Tesmer, P. Podrabsky, H. Bruhn, J. Hilborn, et al. Embolization of experimental wide-necked aneurysms with iodine-containing polyvinyl alcohol solubilized in a low-angiotoxicity solvent. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1849 - 1855. [Abstract] [Full Text] [PDF]

				O. Dudeck, O. Jordan, K.T. Hoffmann, A.F. Okuducu, K. Tesmer, T. Kreuzer-Nagy, D.A. Rufenacht, E. Doelker, and R. Felix Organic solvents as vehicles for precipitating liquid embolics: a comparative angiotoxicity study with superselective injections of Swine rete mirabile. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1900 - 1906. [Abstract] [Full Text] [PDF]

				C. K. Naughton, J. Myles, and A. J. Thomas Jr. The Use of URYX for Reversible Vasectomy in a Rabbit Model J Androl, July 1, 2004; 25(4): 545 - 553. [Abstract] [Full Text] [PDF]

				A. J. Molyneux, S. Cekirge, I. Saatci, and G. Gal Cerebral Aneurysm Multicenter European Onyx (CAMEO) Trial: Results of a Prospective Observational Study in 20 European Centers AJNR Am. J. Neuroradiol., January 1, 2004; 25(1): 39 - 51. [Abstract] [Full Text] [PDF]

				I. Saatci, H. S. Cekirge, E. F. M. Ciceri, M. E. Mawad, A. G. Pamuk, and A. Besim CT and MR Imaging Findings and Their Implications in the Follow-up of Patients with Intracranial Aneurysms Treated with Endosaccular Occlusion with Onyx AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 567 - 578. [Abstract] [Full Text] [PDF]

				Y. P. Gobin, Y. Murayama, K. Milanese, K. Chow, N. R. Gonzalez, G. R. Duckwiler, and F. Vinuela Head and Neck Hypervascular Lesions: Embolization with Ethylene Vinyl Alcohol Copolymer—Laboratory Evaluation in Swine and Clinical Evaluation in Humans Radiology, November 1, 2001; 221(2): 309 - 317. [Abstract] [Full Text] [PDF]