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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 20:519-523 (3 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Pituitary Involvement by Wegener's Granulomatosis: A Report of Two Cases

Gregory L. Katzman^a, Carol A. Langford^a, Michael C. Sneller^a, Myles Koby^a and Nicholas J. Patronas^,a

^a From the Department of Radiology, Clinical Center (G.L.K., N.J.P.), and the National Institute of Allergy and Infectious Diseases (C.A.L., M.C.S.), National Institutes of Health, Bethesda, MD; and the Department of Radiology, University of Maryland Medical Center, Baltimore (M.K.).

Summary: We describe two cases of pituitary involvement by Wegener's granulomatosis. At initial presentation, or during subsequent disease "flares," a pattern of pituitary abnormality was suggested. During periods of remission, we found the pituitary returned to a nearly normal appearance. Loss of the normal posterior pituitary T1 hyperintensity matched a clinical persistence of diabetes insipidus, suggesting there is permanent damage to this structure by the initial disease process.

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