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ARTICLE

99mTc-Bicisate and 99mTc-HMPAO SPECT Imaging in Early Spontaneous Reperfusion of Cerebral Embolism

Kuniaki Ogasawara,a, Kazuo Mizoia, Satoru Fujiwaraa and Takashi Yoshimotoa

a From the Department of Neurosurgery, Kohnan Hospital (K.O., S.F.), and the Department of Neurosurgery, Tohoku University School of Medicine (K.M., T.Y.), Japan.

Summary: Two patients with a cerebral embolism were evaluated by using both 99mTc-ethyl cysteinate dimer (ECD, or Bicisate) and 99mTc-hexamethylpropyleneamine oxime (HMPAO) single-photon emission computed tomography (SPECT). In one patient, 99mTc-ECD SPECT images revealed hypoactivity in a reflow hyperemic area where an infarct was seen later on CT scans. In another patient, a reperfused area showed hyperactivity on 99mTc-ECD SPECT without any abnormality on follow-up CT. 99mTc-ECD represents a potential agent with which to evaluate cerebral tissue viability in early reperfusion after ischemia.




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