American Journal of Neuroradiology 20:637-642 (4 1999)
© 1999 American Society of Neuroradiology
ARTICLE
Histopathologic Analysis of Foci of Signal Loss on Gradient-Echo T2*-Weighted MR Images in Patients with Spontaneous Intracerebral Hemorrhage: Evidence of Microangiopathy-Related Microbleeds
a From the Department of Neurology (F.F., G.R., G.K., P.K., R.S., H-P.H.), the MR Institute (F.F., P.K., R.S.), and the Institute of Pathology, Laboratory of Neuropathology (R.K.), Karl-Franzens University, Graz, Austria.
BACKGROUND AND PURPOSE: Patients with spontaneous intracerebral hemorrhage (ICH) frequently have small areas of signal loss on gradient-echo T2*-weighted MR images, which have been suggested to represent remnants of previous microbleeds. Our aim was to provide histopathologic support for this assumption and to clarify whether the presence and location of microbleeds were associated with microangiopathy.
METHODS: We performed MR imaging and correlative histopathologic examination in 11 formalin-fixed brains of patients who had died of an ICH (age range, 45–90 years).
RESULTS: Focal areas of signal loss on MR images were noted in seven brains. They were seen in a corticosubcortical location in six brains, in the basal ganglia/thalami in five, and infratentorially in three specimens. Histopathologic examination showed focal hemosiderin deposition in 21 of 34 areas of MR signal loss. No other corresponding abnormalities were found; however, hemosiderin deposits were noted without MR signal changes in two brains. All specimens with MR foci of signal loss showed moderate to severe fibrohyalinosis, and there was additional evidence of amyloid angiopathy in two of those brains.
CONCLUSION: Small areas of signal loss on gradient echo T2*-weighted images indicate previous extravasation of blood and are related to bleeding-prone microangiopathy of different origins.
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M. Dichgans, M. Holtmannspotter, J. Herzog, N. Peters, M. Bergmann, and T. A. Yousry Cerebral Microbleeds in CADASIL: A Gradient-Echo Magnetic Resonance Imaging and Autopsy Study Stroke, January 1, 2002; 33(1): 67 - 71. [Abstract] [Full Text] [PDF]
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C. S. Kidwell, J. L. Saver, J. P. Villablanca, G. Duckwiler, A. Fredieu, K. Gough, M. C. Leary, S. Starkman, Y. P. Gobin, R. Jahan, et al. Magnetic Resonance Imaging Detection of Microbleeds Before Thrombolysis: An Emerging Application Stroke, January 1, 2002; 33(1): 95 - 98. [Abstract] [Full Text] [PDF]
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S. A. J. Lesnik Oberstein, R. van den Boom, M. A. van Buchem, H. C. van Houwelingen, E. Bakker, E. Vollebregt, M. D. Ferrari, M. H. Breuning, and J. Haan Cerebral microbleeds in CADASIL Neurology, September 25, 2001; 57(6): 1066 - 1070. [Abstract] [Full Text] [PDF]
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D. D. M. Lin, C. G. Filippi, A. B. Steever, and R. D. Zimmerman Detection of Intracranial Hemorrhage: Comparison between Gradient-echo Images and b0 Images Obtained from Diffusion-weighted Echo-planar Sequences AJNR Am. J. Neuroradiol., August 1, 2001; 22(7): 1275 - 1281. [Abstract] [Full Text] [PDF]
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G. Roob, A. Lechner, R. Schmidt, E. Flooh, H.-P. Hartung, and F. Fazekas Frequency and Location of Microbleeds in Patients With Primary Intracerebral Hemorrhage Stroke, November 1, 2000; 31(11): 2665 - 2669. [Abstract] [Full Text] [PDF]
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T. Kinoshita, T. Okudera, H. Tamura, T. Ogawa, and J. Hatazawa Assessment of Lacunar Hemorrhage Associated With Hypertensive Stroke by Echo-Planar Gradient-Echo T2*-Weighted MRI Stroke, July 1, 2000; 31(7): 1646 - 1650. [Abstract] [Full Text] [PDF]
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