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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 20:686-690 (4 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Central Pain after Pontine Infarction Is Associated with Changes in Opioid Receptor Binding: A PET Study with ¹¹C-Diprenorphine

Frode Willoch^,a, Thomas Rudolf Tölle^a, Hans Jürgen Wester^a, Frank Munz^a, Axel Petzold^a, Markus Schwaiger^a, Bastian Conrad^a and Peter Bartenstein^a

^a From the Departments of Nuclear Medicine (F.W., H.J.W., F.M., M.S., P.B.) and Neurology (T.R.T., A.P., B.C.), Technische Universität München, Germany; the Department of Pharmacology, University of Oslo, Norway (F.W.); and the Department of Neuroimmunology, Institute of Neurology, University College London, UK (A.P.).

Summary: Using ¹⁸F-fluorodeoxyglucose and ¹¹C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced ¹¹C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that ¹¹C-diprenorphine PET provides unique information for the understanding of central poststroke pain.

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