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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 20:801-806 (5 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Digitized Cerebral Synchrotron Radiation Angiography: Quantitative Evaluation of the Canine Circle of Willis and Its Large and Small Branches

Etsuro Tanaka^a, Akira Tanaka^a, Takafumi Sekka^a, Yoshiro Shinozaki^a, Kazuyuki Hyodo^a, Keiji Umetani^a and Hidezo Mori^,a

^a From the Departments of Physiology (E.T., A.T., Y.S., H.M.) and Surgery (T.S.), Tokai University School of Medicine, Isehara, Japan; the National Laboratory for High Energy Physics, Tsukuba, Japan (K.H.); and Synchrotron Radiation Research Institute, Mikazuki, Hyogo Japan (K.U.)

BACKGROUND AND PURPOSE: Conventional X-ray angiography lacks the sensitivity and spatial resolution needed to detect small amounts of iodinated contrast material and to quantitate diameters of the small vessels in the brain. The purpose of this study was to ascertain whether digitized synchrotron radiation microangiography, with the use of a high-definition TV camera system, can accurately show small cerebral vessels.

METHODS: Six anesthetized dogs were exposed to monochromatic synchrotron radiation with an energy level of 33.3 keV optimized for iodine detection while iodinated contrast material was injected into the brachiocephalic and vertebral arteries. The images were detected with a high-definition TV camera system with a spatial resolution of 30 µm. In all, 26 cerebral angiograms of the circle of Willis with its branches were obtained, and the images were digitized at a workstation.

RESULTS: The small branches of the circle of Willis were clearly visible on all images. Vasodilatation of the circle of Willis and its large and small branches induced by CO₂ inhalation was quantitatively confirmed on the images: for example, the diameter of one small branch was increased from 0.24 ± 0.04 mm to 0.38 ± 0.12 mm. Temporal subtraction improved the image quality.

CONCLUSION: The synchrotron radiation angiographic system is useful for visualizing large and small vessels deep in the brain as well as for quantitating their diameters.

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