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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 20:1228-1231 (8 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Optic Nerve Enlargement in Krabbe's Disease

Blaise V. Jones^a, Todd F. Barron^a and Javad Towfighi^a

^a From the Department of Radiology, Neuroradiology (B.V.J.), Children's Hospital Medical Center, Cincinnati, OH, and the Departments of Pediatrics, Pediatric Neurology (T.F.B.), and Pathology (J.T.), M.S. Hershey Medical Center, Penn State Geisinger Health System, Hershey, PA.

Summary: We report imaging and gross pathologic findings from two cases of Krabbe disease in which there was marked enlargement of the intracranial optic nerves. Numerous globoid cells were observed in the optic nerves at autopsy in one case. Krabbe disease should be included in the differential diagnosis of children with enlargement of the optic nerves.

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