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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 20:1507-1510 (9 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Quantitative MR Diffusion Mapping and Cyclosporine-Induced Neurotoxicity

Stuart C. Coley^a, David A. Porter^a, Fernando Calamante^a, Wui K. Chong^a and Alan Connelly^a

^a From the Department of Neuroradiology (S.C.C., W.K.C.), Great Ormond Street Hospital for Children NHS Trust, and the Radiology and Physics Unit (D.A.P., F.C., A.C.), Institute of Child Health, University College London Medical School, London, England.

Summary: Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.

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