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ARTICLE

Optimization of Gray/White Matter Contrast with Fast Inversion Recovery for Myelin Suppression: A Comparison of Fast Spin-Echo and Echo-Planar MR Imaging Sequences

Leo J. Wolansky,a, Steven G. Findena, Janet Chena, Rafik Hannaa, Andrei I. Holodnya, Imtiaz Ahmada, Wen Ching Liua and Sohail Contractora

a From the Department of Radiology, University of Medicine and Dentistry of New Jersey (UMDNJ).

Summary: We compared two MR imaging sequences, fast inversion recovery for myelin suppression (FIRMS) and echo-planar FIRMS (EP-FIRMS), for depicting gray/white matter contrast. In 18 patients, the frequency bandwidth (BW) was optimized for each sequence; in nine patients, the BW was held constant. In the BW-optimized group, the mean contrast-to-noise ratio (C/N) was three times higher with the FIRMS sequence. In the BW-constant group, the mean C/N was 27% higher with the EP-FIRMS sequence; however, geometric distortion degraded the EP-FIRMS images excessively. For optimal gray/white contrast, FIRMS appears to be the superior pulse sequence.