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American Journal of Neuroradiology 20:1678-1681 (10 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Coexistent Holoprosencephaly and Chiari II Malformation

Nancy Rollins,a, Jeanne Joglara and Jeffery Perlmana

a From the Departments of Radiology (N.R., J.J.) and Pediatrics (J.P.), Children's Medical Center and the University of Texas Southwestern Medical School, Dallas, TX.

Summary: Chiari II malformations and holoprosencephaly have been considered to be brain malformations that differ with respect to teratogenic insult, embryologic mechanism, and morphology. We herein describe coexistent Chiari II malformation and holoprosencephaly that occurred in a viable infant. A review of the literature regarding Chiari II malformations and holoprosencephaly suggests that a disturbance to the mesenchyme in early embryologic life may be the cause of both malformations.




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M. Mittelbronn, R. Beschorner, D. Capper, M. Haist, R. Meyermann, and M. Meyer-Wittkopf
Coincidence of Semilobar Holoprosencephaly and Chiari II Malformation: Correlation of Prenatal Diagnostics and Neuropathologic Findings
J Child Neurol, May 1, 2006; 21(5): 426 - 429.
[Abstract] [PDF]


Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X