American Journal of Neuroradiology 21:133-136 (1 2000)
© 2000 American Society of Neuroradiology
ARTICLE
Reproducibilty of Magnetization Transfer Ratio Histogram–Derived Measures of the Brainin Healthy Volunteers
a From the Neuroimaging Research Unit (M.P.S., G.I., M.A.R., G.M., M.C., L.M., M.F.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Milan, and the Unit of Clinical Epidemiology and Trials (M.P.S.), National Institute for Cancer Research, Genoa, Italy.
Summary: Using two MR scanners, we evaluated the intraobserver, interobserver, image-reimage, and interimager variabilities in the assessment of magnetization transfer ratio (MTR) histograms obtained monthly on four occasions from five healthy volunteers. With multiple observers, the mean coefficients of variations ranged from 2.2% to 8.2% for "pure" image-reimage variability, from 1.2% to 4.9% for interobserver variability, and from 2.1% to 4.9% for image-reimage variability. The mean intraobserver coefficients of variations were always lower than 1%. The mean coefficients of variations ranged from 10.2% to 14.6% for pure interimager variability and from 8.6% to 14.3% for interimager variability with multiple observers. Interimager variability accounted for 96.0% of the overall variability of average MTR, for 96.7% of peak location, and for 41.1% of the peak height. The use of different MR scanners is the main source of variability when obtaining MTR histograms.
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