American Journal of Neuroradiology 21:1881-1884 (11 2000)
© 2000 American Society of Neuroradiology
TECHNICAL NOTE
Using 80 kVp versus 120 kVp in Perfusion CT Measurement of Regional Cerebral Blood Flow
a From the Department of Diagnostic and Interventional Radiology (M.W., P.M., P.S., R.M.), University Hospital, 1011 Lausanne, Switzerland ; the Institute of Applied Radiophysics (F.R.V., J-F.V.), Grand-Pré 1, 1007 Lausanne, Switzerland; and the Signal Processing Laboratory (J-P.T.), Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland.
b Address reprint requests to Reto Meuli, Associate Professor, Department of Diagnostic and Interventional Radiology, University Hospital, CHUV—BH10, 1011 Lausanne, Switzerland.
Summary: Perfusion CT studies of regional cerebral blood flow (rCBF), involving sequential acquisition of cerebral CT sections during IV contrast material administration, have classically been reported to be achieved at 120 kVp. We hypothesized that using 80 kVp should result in the same image quality while significantly lowering the patient's radiation dose, and we evaluated this assumption.
In five patients undergoing cerebral CT survey, one section level was imaged at 120 kVp and 80 kVp, before and after IV administration of iodinated contrast material. These four cerebral CT sections obtained in each patient were analyzed with special interest to contrast, noise, and radiation dose.
Contrast enhancement at 80 kVp is significantly increased (P < .001), as well as contrast between gray matter and white matter after contrast enhancement (P < .001). Mean noise at 80 kVp is not statistically different (P = .042). Finally, performance of perfusion CT studies at 80 kVp, keeping mAs constant, lowers the radiation dose by a factor of 2.8.
We, thus, conclude that 80 kVp acquisition of perfusion CT studies of rCBF will result in increased contrast enhancement and should improve rCBF analysis, with a reduced patient's irradiation.