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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 21:301-307 (2 2000)
© 2000 American Society of Neuroradiology

ARTICLE

Magnetoencephalography in Children with Landau-Kleffner Syndrome and Acquired Epileptic Aphasia

David F. Sobel^,a, Maung Aung^a, Hiroshi Otsubo^a and Michael C. Smith^a

^a From the Divisions of Neuroradiology (D.F.S.) and Neurology (M.A.), Scripps Clinic, La Jolla, CA; the Division of Neurology (H.O.), The Hospital for Sick Children, Toronto, Canada; and the Epilepsy Center (M.C.S.), Department of Neurological Science, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL.

BACKGROUND AND PURPOSE: Landau-Kleffner syndrome (LKS) is epileptiform aphasia acquired during childhood and occurring in children with previously normal language development. The epileptiform activity in these children is thought to result in a functional ablation of eloquent speech areas. The purpose of this study was to investigate the usefulness of magnetoencephalography (MEG) for localizing the source of epileptiform activity in these patients.

METHODS: Nineteen patients with acquired aphasia and a suspected diagnosis of LKS were referred for MEG evaluation. Patients ranged in age from 4 to 14 years. Fourteen MEG studies were performed on a 74-channel system, four on a 148-channel whole-head system, and one on a 37-channel system.

RESULTS: Thirteen of the 19 patients had perisylvian MEG spikes. In 10 of the patients, the spikes were bilateral, and in three they were unilateral. Four other patients had non-sylvian spikes, and two patients had no spikes recorded. The results of MR imaging were normal or noncontributory for all 19 patients.

CONCLUSIONS: MEG can play a useful role in evaluating children with LKS and acquired epileptiform aphasia, both in diagnosis and in aiding presurgical localization of epileptiform activity when surgery is being considered.

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