Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sobel, D. F. Articles by Smith, M. C. Search for Related Content PubMed PubMed Citation Articles by Sobel, D. F. Articles by Smith, M. C.

American Journal of Neuroradiology 21:301-307 (2 2000)
© 2000 American Society of Neuroradiology

ARTICLE

Magnetoencephalography in Children with Landau-Kleffner Syndrome and Acquired Epileptic Aphasia

David F. Sobel^,a, Maung Aung^a, Hiroshi Otsubo^a and Michael C. Smith^a

^a From the Divisions of Neuroradiology (D.F.S.) and Neurology (M.A.), Scripps Clinic, La Jolla, CA; the Division of Neurology (H.O.), The Hospital for Sick Children, Toronto, Canada; and the Epilepsy Center (M.C.S.), Department of Neurological Science, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL.

BACKGROUND AND PURPOSE: Landau-Kleffner syndrome (LKS) is epileptiform aphasia acquired during childhood and occurring in children with previously normal language development. The epileptiform activity in these children is thought to result in a functional ablation of eloquent speech areas. The purpose of this study was to investigate the usefulness of magnetoencephalography (MEG) for localizing the source of epileptiform activity in these patients.

METHODS: Nineteen patients with acquired aphasia and a suspected diagnosis of LKS were referred for MEG evaluation. Patients ranged in age from 4 to 14 years. Fourteen MEG studies were performed on a 74-channel system, four on a 148-channel whole-head system, and one on a 37-channel system.

RESULTS: Thirteen of the 19 patients had perisylvian MEG spikes. In 10 of the patients, the spikes were bilateral, and in three they were unilateral. Four other patients had non-sylvian spikes, and two patients had no spikes recorded. The results of MR imaging were normal or noncontributory for all 19 patients.

CONCLUSIONS: MEG can play a useful role in evaluating children with LKS and acquired epileptiform aphasia, both in diagnosis and in aiding presurgical localization of epileptiform activity when surgery is being considered.

This article has been cited by other articles:

				P. Anninos, A. Kotini, A. Tsalkidis, V. Dipla, and A. Chatzimichael Magnetoencephalography Evaluation of Febrile Seizures in Young Children J Child Neurol, January 1, 2010; 25(1): 61 - 66. [Abstract] [PDF]

				K. Fukao, Y. Inoue, and K. Yagi Magnetoencephalographic Characteristics of Psychosis in Temporal Lobe Epilepsy J Neuropsychiatry Clin Neurosci, November 1, 2009; 21(4): 455 - 462. [Abstract] [Full Text] [PDF]

				A. Ochi, H. Otsubo, R. Sharma, A. Hunjan, J. T. Rutka, S. H. Chuang, K. Kamijo, T. Yamazaki, P. Quint, L. Kurelowech, et al. Comparison of Electroencephalographic Dipoles of Interictal Spikes from Prolonged Scalp Video- Electroencephalography and Magnetoencephalographic Dipoles from Short-Term Recording in Children With Extratemporal Lobe Epilepsy J Child Neurol, September 1, 2001; 16(9): 661 - 667. [Abstract] [PDF]

				H. Otsubo and O. C. Snead Topical Review: Magnetoencephalography and Magnetic Source Imaging in Children J Child Neurol, April 1, 2001; 16(4): 227 - 235. [Abstract] [PDF]