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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 21:479-484 (3 2000)
© 2000 American Society of Neuroradiology

ARTICLE

Cortical Laminar Necrosis Caused by Immunosuppressive Therapy and Chemotherapy

Nuria Bargalló^,a, Marta Burrel^a, Joan Berenguer^a, Federico Cofan^a, Laura Buñesch^a and Josep M. Mercader^a

^a From the Department of Radiology (N.B., M.B., J.B., L.B., J.M.M.) and the Renal Transplant Unit (F.C.), Hospital Clínic Provincial de Barcelona, Spain.

Summary: We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). Initial neuroradiologic studies showed cortical and white matter involvement. Follow-up studies showed cortical hyperintense lesions on T1-weighted MR images, consistent with cortical laminar necrosis. The clinical and radiologic data indicate that a transient hypoxic-ischemic process could have been responsible for the encephalic lesions in these three patients.

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