American Journal of Neuroradiology 21:968-970 (5 2000)
© 2000 American Society of Neuroradiology
ARTICLE
Iatrogenic Arterial Spasm Relieved by Intraarterial Mannitol Infusion
a From the Departments of Neurology and Neurosurgery, Oregon Health Sciences University, Portland, OR.
Summary: Catheter placement for blood brainbarrier disruption and enhanced chemotherapy delivery can sometimes trigger arterial spasm of moderate-to-severe degree. A slow infusion of a small quantity of intraarterially administered mannitol (10 mL of 25% mannitol) was evaluated as a means to obtain a rapid resolution of catheter placementinduced spasm. We prospectively report 12 consecutive cases of blood brainbarrier disruption among patients who developed catheter placementinduced spasm that was treated by this means without side effects, resulting in rapid resolution of spasm.
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