Advanced

AJNR - American Journal of Neuroradiology

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Smith, J. K. Articles by Castillo, M. Search for Related Content PubMed PubMed Citation Articles by Smith, J. K. Articles by Castillo, M.

American Journal of Neuroradiology 21:1084-1089 (6 2000)
© 2000 American Society of Neuroradiology

ARTICLE

Effects of Contrast Material on Single-volume Proton MR Spectroscopy

J. Keith Smith^,a, Lester Kwock^a and Mauricio Castillo^a

^a From the Department of Radiology, CB 7510, University of North Carolina School of Medicine, Chapel Hill, NC 27599.

BACKGROUND AND PURPOSE: Administration of contrast material before proton MR spectroscopy may allow more accurate placement of the volume of interest, particularly in tumors; yet, some data have suggested that contrast material may alter the results of MR spectroscopy. To determine the validity of this contention, we performed pre- and postcontrast MR spectroscopy in patients with brain tumors and compared the results with those obtained from a phantom.

METHODS: Ten patients with astrocytomas were examined with single-volume MR spectroscopy before and after administration of contrast material. Voxel placement was identical for all studies. Peak area, peak height, and width at half maximum were measured for N-acetyl aspartate (NAA), creatine (Cr), and choline (Cho) in all studies. A phantom containing a 10-mmol concentration of NAA, Cr, and Cho was prepared in phosphate-buffered saline and mixed with contrast concentrations varying from 0.1 to 1.0 mmol. The phantom was studied by MR spectroscopy with the same parameters as used for the clinical studies.

RESULTS: No significant differences were found between the pre- and postcontrast MR spectroscopy studies for the three parameters measured. In phantom studies, there was a significant decline in the Cho peak area and height and an increase in the width at half maximum as the concentration of contrast material increased from 0.1 to 1.0 mmol. NAA and Cr peaks showed no significant changes in peak height or area.

CONCLUSION: Contrast material may be administered before clinical MR spectroscopy without affecting its interpretation.

This article has been cited by other articles:

				Y. Kato, D. A. Holm, B. Okollie, and D. Artemov Noninvasive detection of temozolomide in brain tumor xenografts by magnetic resonance spectroscopy Neuro Oncology, October 20, 2009; (2009) nop006v1. [Abstract] [Full Text] [PDF]

				M. V. Spampinato, J. K. Smith, L. Kwock, M. Ewend, J. D. Grimme, D. L. A. Camacho, and M. Castillo Cerebral Blood Volume Measurements and Proton MR Spectroscopy in Grading of Oligodendroglial Tumors Am. J. Roentgenol., January 1, 2007; 188(1): 204 - 212. [Abstract] [Full Text] [PDF]

				M. Law, S. Yang, H. Wang, J. S. Babb, G. Johnson, S. Cha, E. A. Knopp, and D. Zagzag Glioma Grading: Sensitivity, Specificity, and Predictive Values of Perfusion MR Imaging and Proton MR Spectroscopic Imaging Compared with Conventional MR Imaging AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 1989 - 1998. [Abstract] [Full Text] [PDF]

				A. M. Saindane, S. Cha, M. Law, X. Xue, E. A. Knopp, and D. Zagzag Proton MR Spectroscopy of Tumefactive Demyelinating Lesions AJNR Am. J. Neuroradiol., September 1, 2002; 23(8): 1378 - 1386. [Abstract] [Full Text] [PDF]

				I. Mader, U. Seeger, R. Weissert, U. Klose, T. Naegele, A. Melms, and W. Grodd Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis Brain, May 1, 2001; 124(5): 953 - 961. [Abstract] [Full Text] [PDF]