American Journal of Neuroradiology 21:1415-1422 (8 2000)
© 2000 American Society of Neuroradiology
ARTICLE
The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex: Implications for Image-guided Neurosurgery
a From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ; UMDNJ-New Jersey Medical School, Newark, NJ (J.W.); and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania.
BACKGROUND AND PURPOSE: Functional MR (fMR) imaging data coregistered to a neurosurgical navigation system have been proposed as guides for the resection of brain tumor in or adjacent to eloquent cortices. The purpose of this study was to compare data obtained from the side of the brain affected by tumor with the contralateral side and to determine if there are physiological limitations of fMR imaging in accurately determining the location of the primary motor cortex.
METHODS: Ten patients with tumors in or directly adjacent to the motor cortex were studied with fMR imaging (finger-tapping paradigm). fMR imaging data were analyzed using multiple R values. These data were coregistered to a real-time intraoperative neurosurgical navigation system.
RESULTS: Significant variability of motor cortex activation patterns was noted among individual patients. The activation volumes on the side of the tumor were significantly smaller compared with the contralateral side for all tumors not previously resected (0.66±0.47). This was most pronounced in glioblastomas (0.27±0.21). We propose that these differences were caused by a loss of autoregulation in the tumor vasculature of glioblastomas and venous effects.
CONCLUSION: Notwithstanding the differences noted, the motor cortex was identified successfully in all patients. This was confirmed by intraoperative physiological identification of the motor cortex and a lack of postoperative neurologic deficit.
This article has been cited by other articles:
 |
|
 |
|
  M. Kocak, J. L. Ulmer, M. Sahin Ugurel, W. Gaggl, and R. W. Prost Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging--Initial Results Radiology, May 1, 2009; 251(2): 485 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.C. Feldman, D. Chu, M. Schulder, M. Barry, E.-S. Cho, and W.-C. Liu The Blood Oxygen Level-Dependent Functional MR Imaging Signal Can Be Used to Identify Brain Tumors and Distinguish Them from Normal Tissue AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 389 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Chen, B. L. Hou, and A. I. Holodny Effect of Age and Tumor Grade on BOLD Functional MR Imaging in Preoperative Assessment of Patients with Glioma Radiology, September 1, 2008; 248(3): 971 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A M BLAMIRE The technology of MRI -- the next 10 years? Br. J. Radiol., August 1, 2008; 81(968): 601 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bizzi, V. Blasi, A. Falini, P. Ferroli, M. Cadioli, U. Danesi, D. Aquino, C. Marras, D. Caldiroli, and G. Broggi Presurgical Functional MR Imaging of Language and Motor Functions: Validation with Intraoperative Electrocortical Mapping Radiology, August 1, 2008; 248(2): 579 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.M. Ruff, N.M. Petrovich Brennan, K.K. Peck, B.L. Hou, V. Tabar, C.W. Brennan, and A.I. Holodny Assessment of the Language Laterality Index in Patients with Brain Tumor Using Functional MR Imaging: Effects of Thresholding, Task Selection, and Prior Surgery AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 528 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Desmurget, F. Bonnetblanc, and H. Duffau Contrasting acute and slow-growing lesions: a new door to brain plasticity Brain, April 1, 2007; 130(4): 898 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Korvenoja, E. Kirveskari, H. J. Aronen, S. Avikainen, A. Brander, J. Huttunen, R. J. Ilmoniemi, J. E. Jaaskelainen, T. Kovala, J. P. Makela, et al. Sensorimotor Cortex Localization: Comparison of Magnetoencephalography, Functional MR Imaging, and Intraoperative Cortical Mapping Radiology, October 1, 2006; 241(1): 213 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Petrella, L. M. Shah, K. M. Harris, A. H. Friedman, T. M. George, J. H. Sampson, J. S. Pekala, and J. T. Voyvodic Preoperative Functional MR Imaging Localization of Language and Motor Areas: Effect on Therapeutic Decision Making in Patients with Potentially Resectable Brain Tumors Radiology, September 1, 2006; 240(3): 793 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.V. Salvan, J.L. Ulmer, W.M. Mueller, H.G.J. Krouwer, R.W. Prost, and G.O. Stroe Presurgical and Intraoperative Mapping of the Motor System in Congenital Truncation of the Precentral Gyrus AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 493 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J.J. Kim, A. I. Holodny, B. L. Hou, K. K. Peck, C. S. Moskowitz, D. L. Bogomolny, and P. H. Gutin The Effect of Prior Surgery on Blood Oxygen Level-Dependent Functional MR Imaging in the Preoperative Assessment of Brain Tumors AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1980 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Krainik, M. Hund-Georgiadis, S. Zysset, and D. Y. von Cramon Regional Impairment of Cerebrovascular Reactivity and BOLD Signal in Adults After Stroke Stroke, June 1, 2005; 36(6): 1146 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murata, K. Sakatani, Y. Katayama, N. Fujiwara, T. Hoshino, C. Fukaya, and T. Yamamoto Decreases of Blood Oxygenation Level--Dependent Signal in the Activated Motor Cortex during Functional Recovery after Resection of a Glioma AJNR Am. J. Neuroradiol., August 1, 2004; 25(7): 1242 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Krainik, H. Duffau, L. Capelle, P. Cornu, A. -L. Boch, J. -F. Mangin, D. Le Bihan, C. Marsault, J. Chiras, and S. Lehericy Role of the healthy hemisphere in recovery after resection of the supplementary motor area Neurology, April 27, 2004; 62(8): 1323 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sailor, M. E. Meyerand, C. H. Moritz, J. Fine, L. Nelson, B. Badie, and V. M. Haughton Supplementary Motor Area Activation in Patients with Frontal Lobe Tumors and Arteriovenous Malformations AJNR Am. J. Neuroradiol., October 1, 2003; 24(9): 1837 - 1842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Ulmer, H. G. Krouwer, W. M. Mueller, M.S. Ugurel, M. Kocak, and L. P. Mark Pseudo-Reorganization of Language Cortical Function at fMR Imaging: A Consequence of Tumor-Induced Neurovascular Uncoupling AJNR Am. J. Neuroradiol., February 1, 2003; 24(2): 213 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I D Wilkinson, C A J Romanowski, D A Jellinek, J Morris, and P D Griffiths Motor functional MRI for pre-operative and intraoperative neurosurgical guidance Br. J. Radiol., February 1, 2003; 76(902): 98 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Murata, K Sakatani, Y Katayama, and C Fukaya Increase in focal concentration of deoxyhaemoglobin during neuronal activity in cerebral ischaemic patients J. Neurol. Neurosurg. Psychiatry, August 1, 2002; 73(2): 182 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Brannen, B. Badie, C. H. Moritz, M. Quigley, M. E. Meyerand, and V. M. Haughton Reliability of Functional MR Imaging with Word-Generation Tasks for Mapping Broca's Area AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1711 - 1718. [Abstract] [Full Text] [PDF]
|
|