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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 22:65-72 (1 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Appearance of Meningiomas on Diffusion-weighted Images: Correlating Diffusion Constants with Histopathologic Findings

Christopher G. Filippi^,a, Mark A. Edgar^a, Aziz M. Ulu^a, Joan C. Prowda^a, Linda A. Heier^a and Robert D. Zimmerman^a

^a From the Departments of Radiology (C.G.F., A.M.U., J.C.P., L.A.H., R.D.Z.) and Pathology (M.A.E.), The New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY.

BACKGROUND AND PURPOSE: Malignant and atypical meningiomas are prone to recurrence and aggressive growth, which affects treatment planning and prognostication. Investigators have used diffusion-weighted imaging and apparent diffusion coefficient (ADC) maps to compare tumor grade and cellularity with the histopathologic findings of intraaxial primary brain neoplasms. The purpose of this study was to determine whether the signal characteristics of meningiomas on diffusion-weighted images correlate with the average diffusion constant (D_av) from ADC maps and histopathologic findings and whether the D_av can reliably distinguish benign from malignant and atypical meningiomas.

METHODS: Seventeen patients (13 women and four men; average age, 55 years) with meningiomas were prospectively studied using routine MR imaging and diffusion-weighted imaging with a single-shot gradient-echo echo-planar pulse sequence (6000/100 [TR/TE]) and b values of 0 and 1000. Signal characteristics on routine MR and diffusion-weighted images were compared with the histopathologic findings after resection by using World Health Organization criteria. D_av values were calculated within the tumor mass from ADC maps before resection.

RESULTS: Four meningiomas were malignant or atypical (World Health Organization grades II and III). D_av values were lower than normal brain values (average, 0.52 ± 0.12 x 10^-5cm²/s; range, 0.45–0.69 x 10^-5cm²/s) and were hyperintense on diffusion-weighted images and hypointense on ADC maps. Thirteen meningiomas were benign. D_av values were higher than normal brain values (average, 1.03 ± 0.29 x 10^-5cm²/s; range, 0.62–1.8 x 10^-5cm²/s). On diffusion-weighted images and ADC maps, most were isointense. Five benign meningiomas had very high D_av values, bright signal on ADC maps, and distinct histopathologic findings, including microcysts, necrotic infarct, and organizing intratumoral hemorrhage. The difference in D_av values between malignant and benign meningiomas was statistically significant (P < .00029).

CONCLUSION: Albeit a small sample size, meningiomas with low D_av tended to be malignant or highly atypical (P < .00029) whereas meningiomas with the highest D_av had increased water content due to either a specific histologic subtype of meningioma or the presence of associated pathologic abnormality.

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