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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 22:1915-1919 (November 2001)
© 2001 American Society of Neuroradiology

BRAIN

Blood Volume of Gliomas Determined by Double-Echo Dynamic Perfusion-Weighted MR Imaging: A Preliminary Study

Hidemasa Uematsu^a, Masayuki Maeda^a, Norihiro Sadato^a, Tsuyoshi Matsuda^a, Yoshiyuki Ishimori^a, Yoshio Koshimoto^a, Hirohiko Kimura^a, Hiroki Yamada^a, Yasutaka Kawamura^a, Yoshiharu Yonekura^a and Harumi Itoh^a

^a From the Department of Radiology (H.U., Y.I., Y.Ko., H.K., H.Y., Y.Ka., H.I.) and the Biological Imaging Research Center (Y.Y.), Fukui Medical University, Fukui; the Department of Radiology, Mie University School of Medicine, Mie (M.M.); the Department of Cerebral Research, National Institute for Physiological Sciences, Aichi (N.S.); and the Application Research Department, Advanced Technology Center, GE Yokogawa Medical Systems Ltd, Tokyo (T.M.), Japan.

BACKGROUND AND PURPOSE: After bolus injection, gadopentetate dimeglumine causes a T2* rate change in permeable tissue that is contaminated by the T1 shortening effect due to the leakage of contrast agent. Therefore, tumor vascularity as reported in previous single-echo perfusion-weighted MR imaging studies has been underestimated. Our aim was to quantitatively and qualitatively evaluate the degree of blood volume of glioblastoma multiformes (GBMs) underestimated by this T1 shortening effect.

METHODS: We used double-echo dynamic MR imaging after a bolus injection of gadopentetate dimeglumine (double-echo perfusion-weighted MR imaging) to simultaneously determine tumor blood volume without (V_T1U) and with (V_T1C) T1 shortening correction. MR imaging was performed in five consecutive patients with GBMs. The ratios of V_T1U and V_T1C were calculated and compared by means of quantitative analysis. The degree of tumor blood volume as determined by V_T1U and V_T1C maps were qualitatively compared using a three-point scale.

RESULTS: All GBMs showed contrast enhancement on postcontrast T1-weighted images. In all subjects, the values of V_T1U were significantly lower than those of V_T1C (mean ± SD, 2.05 ± 1.01 vs. 3.62 ± 1.40, respectively [P < .05]), indicating that tumor blood volume obtained by double-echo perfusion-weighted MR imaging was significantly higher than that by single-echo imaging. In the qualitative analysis, tumor blood volume on the V_T1U map was less conspicuous than that on the V_T1C map.

CONCLUSION: Careful attention should be paid to the underestimation of tumor blood volume resulting from T1 shortening effects when using single-echo perfusion-weighted MR imaging. Double-echo imaging may be more suitable for the analysis of blood volume in GBMs.

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