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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 22:269-272 (2 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Diffusion-weighted MR Imaging in a Case of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes

Kiminobu Yonemura^,a, Yasuhiro Hasegawa^a, Kazumi Kimura^a, Kazuo Minematsu^a and Takenori Yamaguchi^a

^a From the Cerebrovascular Division, Department of Medicine, National Cardiovascular Center, Osaka, Japan.

Summary: In a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS), both T2- and diffusion-weighted MR imaging revealed lesions as hyperintense areas in the occipital lobes early after strokelike episodes. In these lesions, no significant reduction in apparent diffusion coefficient was noted. Apparent diffusion coefficient mapping may help to differentiate strokelike episodes in MELAS from acute ischemic stroke. The strokelike episodes may be related to vasogenic edema and hyperperfusion, which were suggested by our single-photon emission CT and MR imaging studies.

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