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American Journal of Neuroradiology 22:311-313 (2 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Evaluation of Pleomorphic Xanthoastrocytoma by Use of Positron Emission Tomography with [18-F]-Fluorodeoxyglucose and [11C]-Methionine Tracers

Naohiro Tsuyuguchi,a, Yoshimi Matsuokaa, Ichiro Sunadaa, Yasuhiro Matsusakaa and Moududul Haquea

a From the Department of Neurosurgery (N.T., Y.M., M.H.), Osaka City University Medical School; the Department of Neurosurgery (Y.M.), Izumi City Hospital; and the Department of Neurosurgery (I.S.), Saiseikai Ibaraki Hospital.

Summary: We present a case of pleomorphic xanthoastrocytoma (PXA) in a patient with temporal lobe seizures. Imaging sequences included MR, and results of positron emission tomography (PET) with [18F]-fluorodeoxyglucose (FDG) and [11C]-methionine (Met) tracers revealed a hypermetabolic region equivalent or nearly equivalent to normal cerebral cortex, suggesting that the tumor might have malignant potential. Histopathologic findings indicated low-grade glioma. The mechanism for glucose hypermetabolic activity of PXA is not clear; however, the positive findings obtained from FDG-PET may not always indicate the degree of malignancy associated with PXA.




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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X