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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 22:773-776 (4 2001)
© 2001 American Society of Neuroradiology

ARTICLE

T2 Relaxation Measurements in X-linked Adrenoleukodystrophy Performed Using Dual-echo Fast Fluid-attenuated Inversion Recovery MR Imaging

Elias R. Melhem^,a, Theodore F. Gotwald^a, Ryuta Itoh^a, S. James Zinreich^a and Hugo W Moser^a

^a From the Department of Radiology and Radiological Sciences (T.F.G.), The Johns Hopkins Medical Institutions; the F.M. Kirby MR Research Center, Kennedy-Krieger Institute (E.R.M., R.I., S.J.Z.), The Johns Hopkins Medical Institutions; and the Department of Neurogenetics (H.W.M.), Kennedy-Krieger Institute, The Johns Hopkins Medical Institutions, Baltimore, MD.

Summary: The purpose of this study was to determine whether dual-echo fast fluid-attenuated inversion recovery MR imaging and corresponding T2 brain maps can show different zones in the affected white matter of patients with cerebral X-linked adrenoleukodystrophy. Ten male patients with cerebral X-linked adrenoleukodystrophy underwent imaging performed using dual-echo fast fluid-attenuated inversion recovery and dual-echo conventional spin-echo MR sequences. Corresponding T2 relaxation maps of the brain were generated. On the basis of dual-echo fast fluid-attenuated inversion recovery images and T2 maps, the affected white matter could be divided into two distinct zones in four patients with cerebral X-linked adrenoleukodystrophy.