AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wintermark, M.
Right arrow Articles by Meuli, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wintermark, M.
Right arrow Articles by Meuli, R.

American Journal of Neuroradiology 22:905-914 (5 2001)
© 2001 American Society of Neuroradiology

ARTICLE

Simultaneous Measurement of Regional Cerebral Blood Flow by Perfusion CT and Stable Xenon CT: A Validation Study

Max Wintermarka, Jean-Philippe Thirana, Philippe Maedera, Pierre Schnydera and Reto Meuli,a

a From the Department of Diagnostic and Interventional Radiology (M.W., R.M., P.S., P.M.), University Hospital, and the Signal Processing Laboratory (J.-P.T.), Swiss Federal Institute of Technology, Lausanne, Switzerland.

BACKGROUND AND PURPOSE: Knowledge of cerebral blood flow (CBF) alterations in cases of acute stroke could be valuable in the early management of these cases. Among imaging techniques affording evaluation of cerebral perfusion, perfusion CT studies involve sequential acquisition of cerebral CT sections obtained in an axial mode during the IV administration of iodinated contrast material. They are thus very easy to perform in emergency settings. Perfusion CT values of CBF have proved to be accurate in animals, and perfusion CT affords plausible values in humans. The purpose of this study was to validate perfusion CT studies of CBF by comparison with the results provided by stable xenon CT, which have been reported to be accurate, and to evaluate acquisition and processing modalities of CT data, notably the possible deconvolution methods and the selection of the reference artery.

METHODS: Twelve stable xenon CT and perfusion CT cerebral examinations were performed within an interval of a few minutes in patients with various cerebrovascular diseases. CBF maps were obtained from perfusion CT data by deconvolution using singular value decomposition and least mean square methods. The CBF were compared with the stable xenon CT results in multiple regions of interest through linear regression analysis and bilateral t tests for matched variables.

RESULTS: Linear regression analysis showed good correlation between perfusion CT and stable xenon CT CBF values (singular value decomposition method: R2 = 0.79, slope = 0.87; least mean square method: R2 = 0.67, slope = 0.83). Bilateral t tests for matched variables did not identify a significant difference between the two imaging methods (P > .1). Both deconvolution methods were equivalent (P > .1). The choice of the reference artery is a major concern and has a strong influence on the final perfusion CT CBF map.

CONCLUSION: Perfusion CT studies of CBF achieved with adequate acquisition parameters and processing lead to accurate and reliable results.




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
A.A. Konstas, G.V. Goldmakher, T.-Y. Lee, and M.H. Lev
Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis
AJNR Am. J. Neuroradiol., April 1, 2009; 30(4): 662 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Sasaki, K. Kudo, K. Ogasawara, and S. Fujiwara
Tracer Delay-Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT
AJNR Am. J. Neuroradiol., January 1, 2009; 30(1): 188 - 193.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. Murayama, K. Katada, M. Nakane, H. Toyama, H. Anno, M. Hayakawa, D. San Millan Ruiz, and K. J. Murphy
Whole-Brain Perfusion CT Performed with a Prototype 256-Detector Row CT System: Initial Experience
Radiology, January 1, 2009; 250(1): 202 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
T.J. Huynh, B. Murphy, J.A. Pettersen, H. Tu, D.J. Sahlas, L. Zhang, S.P. Symons, S. Black, T.-Y. Lee, and R.I. Aviv
CT Perfusion Quantification of Small-Vessel Ischemic Severity
AJNR Am. J. Neuroradiol., November 1, 2008; 29(10): 1831 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. V. Guadagno, P. S. Jones, F. I. Aigbirhio, D. Wang, T. D. Fryer, D. J. Day, N. Antoun, I. Nimmo-Smith, E. A. Warburton, and J. C. Baron
Selective neuronal loss in rescued penumbra relates to initial hypoperfusion
Brain, October 1, 2008; 131(10): 2666 - 2678.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
E. M. de Lucas, E. Sanchez, A. Gutierrez, A. G. Mandly, E. Ruiz, A. F. Florez, J. Izquierdo, J. Arnaiz, T. Piedra, N. Valle, et al.
CT Protocol for Acute Stroke: Tips and Tricks for General Radiologists
RadioGraphics, October 1, 2008; 28(6): 1673 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. W. Youn, J. H. Kim, Y.-C. Weon, S. H. Kim, M.-K. Han, and H.-J. Bae
Perfusion CT of the Brain Using 40-mm-Wide Detector and Toggling Table Technique for Initial Imaging of Acute Stroke
Am. J. Roentgenol., September 1, 2008; 191(3): W120 - W126.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, et al.
White Matter Thresholds for Ischemic Penumbra and Infarct Core in Patients with Acute Stroke: CT Perfusion Study
Radiology, June 1, 2008; 247(3): 818 - 825.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
F. Gaudiello, V. Colangelo, F. Bolacchi, M. Melis, R. Gandini, F.G. Garaci, V. Cozzolino, R. Floris, and G. Simonetti
Sixty-Four-Section CT Cerebral Perfusion Evaluation in Patients with Carotid Artery Stenosis before and after Stenting with a Cerebral Protection Device
AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 919 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S.K. Ellika, R. Jain, S.C. Patel, L. Scarpace, L.R. Schultz, J.P. Rock, and T. Mikkelsen
Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features
AJNR Am. J. Neuroradiol., November 1, 2007; 28(10): 1981 - 1987.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. Waaijer, M. S. van Leeuwen, M. J.P. van Osch, B. H. van der Worp, F. L. Moll, R. T. H. Lo, W. P. T. M. Mali, and M. Prokop
Changes in Cerebral Perfusion after Revascularization of Symptomatic Carotid Artery Stenosis: CT Measurement
Radiology, November 1, 2007; 245(2): 541 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Zhao, S. Amin-Hanjani, S. Ruland, A.P. Curcio, L. Ostergren, and F.T. Charbel
Regional Cerebral Blood Flow Using Quantitative MR Angiography
AJNR Am. J. Neuroradiol., September 1, 2007; 28(8): 1470 - 1473.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. P. Coles
Imaging after brain injury
Br. J. Anaesth., July 1, 2007; 99(1): 49 - 60.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. A. Strauss, J. Lazovic, M. Wintermark, and D. H. Morton
Multimodal imaging of striatal degeneration in Amish patients with glutaryl-CoA dehydrogenase deficiency
Brain, July 1, 2007; 130(7): 1905 - 1920.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Waaijer, I.C. van der Schaaf, B.K. Velthuis, M. Quist, M.J.P. van Osch, E.P.A. Vonken, M.S. van Leeuwen, and M. Prokop
Reproducibility of Quantitative CT Brain Perfusion Measurements in Patients with Symptomatic Unilateral Carotid Artery Stenosis
AJNR Am. J. Neuroradiol., May 1, 2007; 28(5): 927 - 932.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. W. Parsons, E. M. Pepper, G. A. Bateman, Y. Wang, and C. R. Levi
Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT
Neurology, March 6, 2007; 68(10): 730 - 736.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Chen, M.-H. Shyr, T.-Y. Chen, H.-Y. Lai, C.-C. Lin, and P.-S. Yen
Dynamic CT Perfusion Imaging with Acetazolamide Challenge for Evaluation of Patients with Unilateral Cerebrovascular Steno-Occlusive Disease.
AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1876 - 1881.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
Q. S. Ng, V. Goh, E. Klotz, H. Fichte, M. I. Saunders, P. J. Hoskin, and A. R. Padhani
Quantitative Assessment of Lung Cancer Perfusion Using MDCT: Does Measurement Reproducibility Improve with Greater Tumor Volume Coverage?
Am. J. Roentgenol., October 1, 2006; 187(4): 1079 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
B.D. Murphy, A.J. Fox, D.H. Lee, D.J. Sahlas, S.E. Black, M.J. Hogan, S.B. Coutts, A.M. Demchuk, M. Goyal, R.I. Aviv, et al.
Identification of Penumbra and Infarct in Acute Ischemic Stroke Using Computed Tomography Perfusion-Derived Blood Flow and Blood Volume Measurements
Stroke, July 1, 2006; 37(7): 1771 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
I. van der Schaaf, M. J. Wermer, Y. van der Graaf, R. G. Hoff, G.J.E. Rinkel, and B. K. Velthuis
CT after subarachnoid hemorrhage: Relation of cerebral perfusion to delayed cerebral ischemia
Neurology, May 23, 2006; 66(10): 1533 - 1538.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
K W Muir, H M Halbert, T A Baird, M McCormick, and E Teasdale
Visual evaluation of perfusion computed tomography in acute stroke accurately estimates infarct volume and tissue viability
J. Neurol. Neurosurg. Psychiatry, March 1, 2006; 77(3): 334 - 339.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
I. van der Schaaf, M. J. Wermer, Y. van der Graaf, B. K. Velthuis, C. I.B van de Kraats, and G. J.E. Rinkel
Prognostic Value of Cerebral Perfusion-Computed Tomography in the Acute Stage After Subarachnoid Hemorrhage for the Development of Delayed Cerebral Ischemia
Stroke, February 1, 2006; 37(2): 409 - 413.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Wintermark, N.U. Ko, W.S. Smith, S. Liu, R.T. Higashida, and W.P. Dillon
Vasospasm after Subarachnoid Hemorrhage: Utility of Perfusion CT and CT Angiography on Diagnosis and Management
AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 26 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
I. van der Schaaf, E.-J. Vonken, A. Waaijer, B. Velthuis, M. Quist, and T. van Osch
Influence of Partial Volume on Venous Output and Arterial Input Function
AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 46 - 50.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
D. Gandhi, D.B. Chepeha, T. Miller, R.C. Carlos, C.R. Bradford, R. Karamchandani, F. Worden, A. Eisbruch, T.N. Teknos, G.T. Wolf, et al.
Correlation between initial and early follow-up CT perfusion parameters with endoscopic tumor response in patients with advanced squamous cell carcinomas of the oropharynx treated with organ-preservation therapy.
AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 101 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
R. Moftakhar, A. S. Turk, D. B. Niemann, S. Hussain, S. Rajpal, T. Cook, M. Geraghty, B. Aagaard-Kienitz, P. A. Turski, and G. C. Newman
Effects of Carotid or Vertebrobasilar Stent Placement on Cerebral Perfusion and Cognition
AJNR Am. J. Neuroradiol., August 1, 2005; 26(7): 1772 - 1780.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. C. Hemphill III, W. S. Smith, D. C. Sonne, D. Morabito, and G. T. Manley
Relationship between Brain Tissue Oxygen Tension and CT Perfusion: Feasibility and Initial Results
AJNR Am. J. Neuroradiol., May 1, 2005; 26(5): 1095 - 1100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
Z. Rumboldt, R. Al-Okaili, and J. P. Deveikis
Perfusion CT for Head and Neck Tumors: Pilot Study
AJNR Am. J. Neuroradiol., May 1, 2005; 26(5): 1178 - 1185.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Wintermark, N. J. Fischbein, W. S. Smith, N. U. Ko, M. Quist, and W. P. Dillon
Accuracy of Dynamic Perfusion CT with Deconvolution in Detecting Acute Hemispheric Stroke
AJNR Am. J. Neuroradiol., January 1, 2005; 26(1): 104 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
S F S Halpin
Brain imaging using multislice CT: a personal perspective
Br. J. Radiol., December 1, 2004; 77(suppl_1): S20 - S26.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Galvez, G. E. York II, and J. D. Eastwood
CT Perfusion Parameter Values in Regions of Diffusion Abnormalities
AJNR Am. J. Neuroradiol., August 1, 2004; 25(7): 1205 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Wintermark, G. van Melle, P. Schnyder, J.-P. Revelly, F. Porchet, L. Regli, R. Meuli, P. Maeder, and R. Chiolero
Admission Perfusion CT: Prognostic Value in Patients with Severe Head Trauma
Radiology, July 1, 2004; 232(1): 211 - 220.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. Wintermark, D. Lepori, J. Cotting, E. Roulet, G. van Melle, R. Meuli, P. Maeder, L. Regli, F. R. Verdun, T. Deonna, et al.
Brain Perfusion in Children: Evolution With Age Assessed by Quantitative Perfusion Computed Tomography
Pediatrics, June 1, 2004; 113(6): 1642 - 1652.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
E. G. Hoeffner, I. Case, R. Jain, S. K. Gujar, G. V. Shah, J. P. Deveikis, R. C. Carlos, B. G. Thompson, M. R. Harrigan, and S. K. Mukherji
Cerebral Perfusion CT: Technique and Clinical Applications
Radiology, June 1, 2004; 231(3): 632 - 644.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. Jain, E. G. Hoeffner, J. P. Deveikis, M. R. Harrigan, B. G. Thompson, and S. K. Mukherji
Carotid Perfusion CT with Balloon Occlusion and Acetazolamide Challenge Test: Feasibility
Radiology, June 1, 2004; 231(3): 906 - 913.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Wintermark, W. S. Smith, N. U. Ko, M. Quist, P. Schnyder, and W. P. Dillon
Dynamic Perfusion CT: Optimizing the Temporal Resolution and Contrast Volume for Calculation of Perfusion CT Parameters in Stroke Patients
AJNR Am. J. Neuroradiol., May 1, 2004; 25(5): 720 - 729.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Yamada, S. Yoshimura, Y. Kaku, T. Iwama, H. Watarai, T. Andoh, and N. Sakai
Prediction of Neurologic Deterioration in Patients with Lacunar Infarction in the Territory of the Lenticulostriate Artery Using Perfusion CT
AJNR Am. J. Neuroradiol., March 1, 2004; 25(3): 402 - 408.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
H S Markus
Cerebral perfusion and stroke
J. Neurol. Neurosurg. Psychiatry, March 1, 2004; 75(3): 353 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
K A Miles
Perfusion CT for the assessment of tumour vascularity: which protocol?
Br. J. Radiol., December 1, 2003; 76(suppl_1): S36 - S42.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. D. Eastwood, M. H. Lev, M. Wintermark, C. Fitzek, D. P. Barboriak, D. M. Delong, T.-Y. Lee, T. Azhari, M. Herzau, V. R. Chilukuri, et al.
Correlation of Early Dynamic CT Perfusion Imaging with Whole-Brain MR Diffusion and Perfusion Imaging in Acute Hemispheric Stroke
AJNR Am. J. Neuroradiol., October 1, 2003; 24(9): 1869 - 1875.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
K A Miles and M R Griffiths
Perfusion CT: a worthwhile enhancement?
Br. J. Radiol., April 1, 2003; 76(904): 220 - 231.
[Full Text] [PDF]

Home page
 StrokeHome page
H. P. Adams Jr, R. J. Adams, T. Brott, G. J. del Zoppo, A. Furlan, L. B. Goldstein, R. L. Grubb, R. Higashida, C. Kidwell, T. G. Kwiatkowski, et al.
Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association
Stroke, April 1, 2003; 34(4): 1056 - 1083.
[Full Text] [PDF]

Home page
 StrokeHome page
R. E. Latchaw, H. Yonas, G. J. Hunter, W. T.C. Yuh, T. Ueda, A. G. Sorensen, J. L. Sunshine, J. Biller, L. Wechsler, R. Higashida, et al.
Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia: A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, From the Council on Cardiovascular Radiology of the American Heart Association
Stroke, April 1, 2003; 34(4): 1084 - 1104.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. D. Eastwood, M. H. Lev, and J. M. Provenzale
Perfusion CT with Iodinated Contrast Material
Am. J. Roentgenol., January 1, 2003; 180(1): 3 - 12.
[Full Text] [PDF]

Home page
 StrokeHome page
M. Wintermark, M. Reichhart, O. Cuisenaire, P. Maeder, J.-P. Thiran, P. Schnyder, J. Bogousslavsky, and R. Meuli
Comparison of Admission Perfusion Computed Tomography and Qualitative Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in Acute Stroke Patients
Stroke, August 1, 2002; 33(8): 2025 - 2031.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
H. C. Roberts MD, T. P.L. Roberts MD, and W. P. Dillon MD
CT Perfusion Flow Assessment: "Up and Coming" or "Off and Running"?
AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1018 - 1019.
[Full Text] [PDF]


Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X